Axotomy-induced regulation of c-Jun expression in regenerating rat retinal ganglion cells.

Journal Article

Antibodies to c-Jun, JunD, JunB, c-Fos, FosB and Krox-24 proteins were used to examine the expression of these transcription factors in identified adult rat retinal ganglion cells with regenerating axons in a peripheral nerve graft. First, expression in ganglion cells 1 month after graft placement was compared to expression in these neurons 5 to 6 months after grafting. Whereas strong c-Jun expression was seen in most ganglion cells one month after grafting, most 5- to 6-month ganglion cells showed only basal expression. The maintained nucleolar expression of FosB in both ganglion cell groups was the only other transcription factor seen. Second, transcription factor expression was examined in these short- and long-term regenerating neurons after a second axotomy caused by graft transection and compared to the effects of a single axotomy on expression in non-regenerating ganglion cells. Only c-Jun was re-expressed in the regenerating ganglion cells after re-axotomy.

Full Text

Duke Authors

Cited Authors

  • Robinson, GA

Published Date

  • May 1995

Published In

Volume / Issue

  • 30 / 1

Start / End Page

  • 61 - 69

PubMed ID

  • 7609645

International Standard Serial Number (ISSN)

  • 0169-328X

Language

  • eng

Conference Location

  • Netherlands