Axotomy-induced regulation of c-Jun expression in regenerating rat retinal ganglion cells.
Published
Journal Article
Antibodies to c-Jun, JunD, JunB, c-Fos, FosB and Krox-24 proteins were used to examine the expression of these transcription factors in identified adult rat retinal ganglion cells with regenerating axons in a peripheral nerve graft. First, expression in ganglion cells 1 month after graft placement was compared to expression in these neurons 5 to 6 months after grafting. Whereas strong c-Jun expression was seen in most ganglion cells one month after grafting, most 5- to 6-month ganglion cells showed only basal expression. The maintained nucleolar expression of FosB in both ganglion cell groups was the only other transcription factor seen. Second, transcription factor expression was examined in these short- and long-term regenerating neurons after a second axotomy caused by graft transection and compared to the effects of a single axotomy on expression in non-regenerating ganglion cells. Only c-Jun was re-expressed in the regenerating ganglion cells after re-axotomy.
Full Text
Duke Authors
Cited Authors
- Robinson, GA
Published Date
- May 1995
Published In
Volume / Issue
- 30 / 1
Start / End Page
- 61 - 69
PubMed ID
- 7609645
Pubmed Central ID
- 7609645
International Standard Serial Number (ISSN)
- 0169-328X
Digital Object Identifier (DOI)
- 10.1016/0169-328x(94)00277-l
Language
- eng
Conference Location
- Netherlands