Survival of adult rat retinal ganglion cells with regrown axons in peripheral nerve grafts: a comparison of graft attachment with suture of fibrin glue.

Journal Article

OBJECT: The goal of this study was to examine whether the method of attachment of a peripheral nerve graft would have an effect on retinal ganglion cell (RGC) regeneration. METHODS: The number of adult rat RGCs with regrown axons in a peripheral nerve graft was compared under two grafting conditions: 1) attachment of the graft to the optic nerve stump made using a suture; and 2) attachment made using fibrin glue. Counts of RGCs retrogradely labeled with FluoroGold from the grafts 1 month after attachment revealed approximately seven times the number of RGCs in the fibrin-glue group compared with the suture group. CONCLUSIONS: The use of fibrin glue may be a useful tool for enhancing the regrowth of central nervous system neuron axons into peripheral nervous system grafts.

Full Text

Duke Authors

Cited Authors

  • Robinson, GA; Madison, RD

Published Date

  • August 2000

Published In

Volume / Issue

  • 93 / 2

Start / End Page

  • 275 - 278

PubMed ID

  • 10930013

International Standard Serial Number (ISSN)

  • 0022-3085

Digital Object Identifier (DOI)

  • 10.3171/jns.2000.93.2.0275

Language

  • eng

Conference Location

  • United States