Manipulations of the mouse femoral nerve influence the accuracy of pathway reinnervation by motor neurons.

Journal Article (Journal Article)

Previous studies using the femoral nerve model in both mice and rats have shown that regenerating motor axons prefer to reinnervate the terminal nerve branch to muscle versus a terminal nerve branch to skin, a process that has been termed preferential motor reinnervation (PMR). If end organ contact with muscle and skin is prevented, this preferential motor reinnervation still occurs in the rat. To better understand the process of preferential motor reinnervation in the mouse, we examined motor neuron reinnervation of muscle and cutaneous pathways without any end organ contact as well as with only cutaneous end organ contact. Surprisingly, there was no preferential motor reinnervation: Motor neurons preferred the cutaneous pathway over the muscle pathway when all end organ contact was prevented and showed an even greater preference for the cutaneous pathway when it was attached to skin.

Full Text

Duke Authors

Cited Authors

  • Robinson, GA; Madison, RD

Published Date

  • March 2005

Published In

Volume / Issue

  • 192 / 1

Start / End Page

  • 39 - 45

PubMed ID

  • 15698617

International Standard Serial Number (ISSN)

  • 0014-4886

Digital Object Identifier (DOI)

  • 10.1016/j.expneurol.2004.10.013


  • eng

Conference Location

  • United States