Skip to main content

Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro.

Publication ,  Journal Article
Nair, S; Zhou, F; Reddy, R; Huang, L; Rouse, BT
Published in: J Exp Med
February 1, 1992

Effective immunity to many infectious agents, particularly viruses, requires a CD8+ cytotoxic T lymphocyte (CTL) response. Understanding how to achieve CTL induction with soluble proteins is important for vaccine development since such antigens are usually not processed appropriately to induce CTL. In the present report, we have demonstrated that a potent primary CTL response against a soluble protein can be achieved by delivering antigen in pH-sensitive liposomes to dendritic cells (DC) either in vivo or in vitro. Since the pH-sensitive liposome delivery system is efficient and easy to use, the approach promises to be valuable both in the study of basic mechanisms in antigen processing, and as a practical means of immunization.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Exp Med

DOI

ISSN

0022-1007

Publication Date

February 1, 1992

Volume

175

Issue

2

Start / End Page

609 / 612

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • T-Lymphocytes, Regulatory
  • T-Lymphocytes, Cytotoxic
  • Ovalbumin
  • Mice, Inbred C57BL
  • Mice
  • Liposomes
  • Immunology
  • Hydrogen-Ion Concentration
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Nair, S., Zhou, F., Reddy, R., Huang, L., & Rouse, B. T. (1992). Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro. J Exp Med, 175(2), 609–612. https://doi.org/10.1084/jem.175.2.609
Nair, S., F. Zhou, R. Reddy, L. Huang, and B. T. Rouse. “Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro.J Exp Med 175, no. 2 (February 1, 1992): 609–12. https://doi.org/10.1084/jem.175.2.609.
Nair, S., et al. “Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro.J Exp Med, vol. 175, no. 2, Feb. 1992, pp. 609–12. Pubmed, doi:10.1084/jem.175.2.609.

Published In

J Exp Med

DOI

ISSN

0022-1007

Publication Date

February 1, 1992

Volume

175

Issue

2

Start / End Page

609 / 612

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • T-Lymphocytes, Regulatory
  • T-Lymphocytes, Cytotoxic
  • Ovalbumin
  • Mice, Inbred C57BL
  • Mice
  • Liposomes
  • Immunology
  • Hydrogen-Ion Concentration
  • Female