Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro.
Publication
, Journal Article
Nair, S; Zhou, F; Reddy, R; Huang, L; Rouse, BT
Published in: J Exp Med
February 1, 1992
Effective immunity to many infectious agents, particularly viruses, requires a CD8+ cytotoxic T lymphocyte (CTL) response. Understanding how to achieve CTL induction with soluble proteins is important for vaccine development since such antigens are usually not processed appropriately to induce CTL. In the present report, we have demonstrated that a potent primary CTL response against a soluble protein can be achieved by delivering antigen in pH-sensitive liposomes to dendritic cells (DC) either in vivo or in vitro. Since the pH-sensitive liposome delivery system is efficient and easy to use, the approach promises to be valuable both in the study of basic mechanisms in antigen processing, and as a practical means of immunization.
Duke Scholars
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Published In
J Exp Med
DOI
ISSN
0022-1007
Publication Date
February 1, 1992
Volume
175
Issue
2
Start / End Page
609 / 612
Location
United States
Related Subject Headings
- Tumor Cells, Cultured
- T-Lymphocytes, Regulatory
- T-Lymphocytes, Cytotoxic
- Ovalbumin
- Mice, Inbred C57BL
- Mice
- Liposomes
- Immunology
- Hydrogen-Ion Concentration
- Female
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Nair, S., Zhou, F., Reddy, R., Huang, L., & Rouse, B. T. (1992). Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro. J Exp Med, 175(2), 609–612. https://doi.org/10.1084/jem.175.2.609
Nair, S., F. Zhou, R. Reddy, L. Huang, and B. T. Rouse. “Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro.” J Exp Med 175, no. 2 (February 1, 1992): 609–12. https://doi.org/10.1084/jem.175.2.609.
Nair S, Zhou F, Reddy R, Huang L, Rouse BT. Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro. J Exp Med. 1992 Feb 1;175(2):609–12.
Nair, S., et al. “Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro.” J Exp Med, vol. 175, no. 2, Feb. 1992, pp. 609–12. Pubmed, doi:10.1084/jem.175.2.609.
Nair S, Zhou F, Reddy R, Huang L, Rouse BT. Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro. J Exp Med. 1992 Feb 1;175(2):609–612.
Published In
J Exp Med
DOI
ISSN
0022-1007
Publication Date
February 1, 1992
Volume
175
Issue
2
Start / End Page
609 / 612
Location
United States
Related Subject Headings
- Tumor Cells, Cultured
- T-Lymphocytes, Regulatory
- T-Lymphocytes, Cytotoxic
- Ovalbumin
- Mice, Inbred C57BL
- Mice
- Liposomes
- Immunology
- Hydrogen-Ion Concentration
- Female