In vivo cytotoxic T lymphocyte induction with soluble proteins administered in liposomes.

Journal Article (Journal Article)

The in vivo induction of a CTL response usually requires that Ag be endogenously synthesized so that appropriate processing can occur. In most of the few examples where successful CTL induction was reported with proteins and peptides, unacceptable adjuvants or means of Ag formulation were used. In the present report, liposomes were used to incorporate the soluble proteins OVA and beta-galactosidase. This simple and convenient to use approach, which requires minimal amounts of Ag, results in priming for a CD8+ CTL response and the establishment of immunologic memory. The liposome approach may not only prove a convenient means of inducing CTL responses in vivo but may also be useful to study the mechanisms of Ag processing.

Full Text

Duke Authors

Cited Authors

  • Reddy, R; Zhou, F; Nair, S; Huang, L; Rouse, BT

Published Date

  • March 1, 1992

Published In

Volume / Issue

  • 148 / 5

Start / End Page

  • 1585 - 1589

PubMed ID

  • 1538138

International Standard Serial Number (ISSN)

  • 0022-1767


  • eng

Conference Location

  • United States