In vivo cytotoxic T lymphocyte induction with soluble proteins administered in liposomes.
Publication
, Journal Article
Reddy, R; Zhou, F; Nair, S; Huang, L; Rouse, BT
Published in: J Immunol
March 1, 1992
The in vivo induction of a CTL response usually requires that Ag be endogenously synthesized so that appropriate processing can occur. In most of the few examples where successful CTL induction was reported with proteins and peptides, unacceptable adjuvants or means of Ag formulation were used. In the present report, liposomes were used to incorporate the soluble proteins OVA and beta-galactosidase. This simple and convenient to use approach, which requires minimal amounts of Ag, results in priming for a CD8+ CTL response and the establishment of immunologic memory. The liposome approach may not only prove a convenient means of inducing CTL responses in vivo but may also be useful to study the mechanisms of Ag processing.
Duke Scholars
Published In
J Immunol
ISSN
0022-1767
Publication Date
March 1, 1992
Volume
148
Issue
5
Start / End Page
1585 / 1589
Location
United States
Related Subject Headings
- beta-Galactosidase
- T-Lymphocytes, Cytotoxic
- Ovalbumin
- Mice, Inbred C57BL
- Mice, Inbred BALB C
- Mice
- Liposomes
- Immunology
- Female
- CD8 Antigens
Citation
APA
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ICMJE
MLA
NLM
Reddy, R., Zhou, F., Nair, S., Huang, L., & Rouse, B. T. (1992). In vivo cytotoxic T lymphocyte induction with soluble proteins administered in liposomes. J Immunol, 148(5), 1585–1589.
Reddy, R., F. Zhou, S. Nair, L. Huang, and B. T. Rouse. “In vivo cytotoxic T lymphocyte induction with soluble proteins administered in liposomes.” J Immunol 148, no. 5 (March 1, 1992): 1585–89.
Reddy R, Zhou F, Nair S, Huang L, Rouse BT. In vivo cytotoxic T lymphocyte induction with soluble proteins administered in liposomes. J Immunol. 1992 Mar 1;148(5):1585–9.
Reddy, R., et al. “In vivo cytotoxic T lymphocyte induction with soluble proteins administered in liposomes.” J Immunol, vol. 148, no. 5, Mar. 1992, pp. 1585–89.
Reddy R, Zhou F, Nair S, Huang L, Rouse BT. In vivo cytotoxic T lymphocyte induction with soluble proteins administered in liposomes. J Immunol. 1992 Mar 1;148(5):1585–1589.
Published In
J Immunol
ISSN
0022-1767
Publication Date
March 1, 1992
Volume
148
Issue
5
Start / End Page
1585 / 1589
Location
United States
Related Subject Headings
- beta-Galactosidase
- T-Lymphocytes, Cytotoxic
- Ovalbumin
- Mice, Inbred C57BL
- Mice, Inbred BALB C
- Mice
- Liposomes
- Immunology
- Female
- CD8 Antigens