New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties.
Journal Article (Journal Article)
A series of 13 novel hybrid molecules designed to possess both free radical scavenging activity and to stimulate the beta(3)-adrenoceptors in order to improve antidiabetic effect and to restore insulin sensitivity was synthesized and evaluated. Compounds were of quinolyl-, isoquinolyl-, pyridoindolyl- or carbazolyloxypropanolamine structure with a terminal amino group of benzopyranolyl-, di-tert-butylphenolyl- or methoxyindolyl-type. Some of the products possessed both the expected activities.
Full Text
Duke Authors
Cited Authors
- Aubriot, S; Nicolle, E; Lattier, M; Morel, C; Cao, W; Daniel, KW; Collins, S; Leclerc, G; Faure, P
Published Date
- January 21, 2002
Published In
Volume / Issue
- 12 / 2
Start / End Page
- 209 - 212
PubMed ID
- 11755356
International Standard Serial Number (ISSN)
- 0960-894X
Digital Object Identifier (DOI)
- 10.1016/s0960-894x(01)00716-8
Language
- eng
Conference Location
- England