New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties.

Journal Article (Journal Article)

A series of 13 novel hybrid molecules designed to possess both free radical scavenging activity and to stimulate the beta(3)-adrenoceptors in order to improve antidiabetic effect and to restore insulin sensitivity was synthesized and evaluated. Compounds were of quinolyl-, isoquinolyl-, pyridoindolyl- or carbazolyloxypropanolamine structure with a terminal amino group of benzopyranolyl-, di-tert-butylphenolyl- or methoxyindolyl-type. Some of the products possessed both the expected activities.

Full Text

Duke Authors

Cited Authors

  • Aubriot, S; Nicolle, E; Lattier, M; Morel, C; Cao, W; Daniel, KW; Collins, S; Leclerc, G; Faure, P

Published Date

  • January 21, 2002

Published In

Volume / Issue

  • 12 / 2

Start / End Page

  • 209 - 212

PubMed ID

  • 11755356

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/s0960-894x(01)00716-8


  • eng

Conference Location

  • England