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From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors.

Publication ,  Journal Article
Collins, S; Caron, MG; Lefkowitz, RJ
Published in: Trends Biochem Sci
January 1992

Transmembrane signaling systems relay information from the exterior to the interior of a cell, through a series of complex protein-protein interactions and second messenger cascades. One such system consists of the G-protein-coupled receptors, which interact with G proteins upon ligand binding, and in turn activate an effector molecule. The receptor is the first component in this signaling cascade and is subject to considerable regulation. Recent studies have shown that these regulatory events can occur at the levels of receptor protein modification and receptor gene expression. Interestingly, some of these processes appear to be mediated by the same second messenger systems that these receptors activate, which leads to various forms of positive and negative feedback regulation.

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Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

January 1992

Volume

17

Issue

1

Start / End Page

37 / 39

Location

England

Related Subject Headings

  • Transcription Factors
  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Molecular Sequence Data
  • Ligands
  • Gene Expression
  • GTP-Binding Proteins
  • Down-Regulation
  • Developmental Biology
  • Cyclic AMP
 

Citation

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Collins, S., Caron, M. G., & Lefkowitz, R. J. (1992). From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors. Trends Biochem Sci, 17(1), 37–39. https://doi.org/10.1016/0968-0004(92)90425-9
Collins, S., M. G. Caron, and R. J. Lefkowitz. “From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors.Trends Biochem Sci 17, no. 1 (January 1992): 37–39. https://doi.org/10.1016/0968-0004(92)90425-9.
Collins S, Caron MG, Lefkowitz RJ. From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors. Trends Biochem Sci. 1992 Jan;17(1):37–9.
Collins, S., et al. “From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors.Trends Biochem Sci, vol. 17, no. 1, Jan. 1992, pp. 37–39. Pubmed, doi:10.1016/0968-0004(92)90425-9.
Collins S, Caron MG, Lefkowitz RJ. From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors. Trends Biochem Sci. 1992 Jan;17(1):37–39.
Journal cover image

Published In

Trends Biochem Sci

DOI

ISSN

0968-0004

Publication Date

January 1992

Volume

17

Issue

1

Start / End Page

37 / 39

Location

England

Related Subject Headings

  • Transcription Factors
  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Molecular Sequence Data
  • Ligands
  • Gene Expression
  • GTP-Binding Proteins
  • Down-Regulation
  • Developmental Biology
  • Cyclic AMP