From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors.
Published
Journal Article (Review)
Transmembrane signaling systems relay information from the exterior to the interior of a cell, through a series of complex protein-protein interactions and second messenger cascades. One such system consists of the G-protein-coupled receptors, which interact with G proteins upon ligand binding, and in turn activate an effector molecule. The receptor is the first component in this signaling cascade and is subject to considerable regulation. Recent studies have shown that these regulatory events can occur at the levels of receptor protein modification and receptor gene expression. Interestingly, some of these processes appear to be mediated by the same second messenger systems that these receptors activate, which leads to various forms of positive and negative feedback regulation.
Full Text
Duke Authors
Cited Authors
- Collins, S; Caron, MG; Lefkowitz, RJ
Published Date
- January 1, 1992
Published In
Volume / Issue
- 17 / 1
Start / End Page
- 37 - 39
PubMed ID
- 1316650
Pubmed Central ID
- 1316650
International Standard Serial Number (ISSN)
- 0968-0004
Digital Object Identifier (DOI)
- 10.1016/0968-0004(92)90425-9
Language
- eng
Conference Location
- England