Beta-adrenergic receptors and regulation of energy expenditure: a family affair.

Published

Journal Article (Review)

The family of adrenergic receptors (ARs) expressed in adipocytes includes three sibling betaARs and two alphaAR cousins. Together they profoundly influence the mobilization of stored fatty acids, secretion of fat-cell derived hormones, and the specialized process of nonshivering thermogenesis in brown adipose tissue. The two types of fat cells that compose adipose tissue, brown and white, are structurally and functionally distinct. Studies on the mechanisms by which individual betaAR regulates these cell-specific functions have recently uncovered new signal transduction cascades involved in processes traditionally ascribed to adenylyl cyclase/cAMP/protein kinase A system. They illustrate how betaAR signaling can orchestrate a coordinated set of intracellular responses for fine control of metabolic balance.

Full Text

Duke Authors

Cited Authors

  • Robidoux, J; Martin, TL; Collins, S

Published Date

  • January 2004

Published In

Volume / Issue

  • 44 /

Start / End Page

  • 297 - 323

PubMed ID

  • 14744248

Pubmed Central ID

  • 14744248

Electronic International Standard Serial Number (EISSN)

  • 1545-4304

International Standard Serial Number (ISSN)

  • 0362-1642

Digital Object Identifier (DOI)

  • 10.1146/annurev.pharmtox.44.101802.121659

Language

  • eng