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Beta-adrenergic receptors and regulation of energy expenditure: a family affair.

Publication ,  Journal Article
Robidoux, J; Martin, TL; Collins, S
Published in: Annu Rev Pharmacol Toxicol
2004

The family of adrenergic receptors (ARs) expressed in adipocytes includes three sibling betaARs and two alphaAR cousins. Together they profoundly influence the mobilization of stored fatty acids, secretion of fat-cell derived hormones, and the specialized process of nonshivering thermogenesis in brown adipose tissue. The two types of fat cells that compose adipose tissue, brown and white, are structurally and functionally distinct. Studies on the mechanisms by which individual betaAR regulates these cell-specific functions have recently uncovered new signal transduction cascades involved in processes traditionally ascribed to adenylyl cyclase/cAMP/protein kinase A system. They illustrate how betaAR signaling can orchestrate a coordinated set of intracellular responses for fine control of metabolic balance.

Duke Scholars

Published In

Annu Rev Pharmacol Toxicol

DOI

ISSN

0362-1642

Publication Date

2004

Volume

44

Start / End Page

297 / 323

Location

United States

Related Subject Headings

  • Thermogenesis
  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Pharmacology & Pharmacy
  • Obesity
  • Lipolysis
  • Humans
  • Energy Metabolism
  • Animals
  • Adipose Tissue
 

Citation

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MLA
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Robidoux, J., Martin, T. L., & Collins, S. (2004). Beta-adrenergic receptors and regulation of energy expenditure: a family affair. Annu Rev Pharmacol Toxicol, 44, 297–323. https://doi.org/10.1146/annurev.pharmtox.44.101802.121659
Robidoux, Jacques, Tonya L. Martin, and Sheila Collins. “Beta-adrenergic receptors and regulation of energy expenditure: a family affair.Annu Rev Pharmacol Toxicol 44 (2004): 297–323. https://doi.org/10.1146/annurev.pharmtox.44.101802.121659.
Robidoux J, Martin TL, Collins S. Beta-adrenergic receptors and regulation of energy expenditure: a family affair. Annu Rev Pharmacol Toxicol. 2004;44:297–323.
Robidoux, Jacques, et al. “Beta-adrenergic receptors and regulation of energy expenditure: a family affair.Annu Rev Pharmacol Toxicol, vol. 44, 2004, pp. 297–323. Pubmed, doi:10.1146/annurev.pharmtox.44.101802.121659.
Robidoux J, Martin TL, Collins S. Beta-adrenergic receptors and regulation of energy expenditure: a family affair. Annu Rev Pharmacol Toxicol. 2004;44:297–323.

Published In

Annu Rev Pharmacol Toxicol

DOI

ISSN

0362-1642

Publication Date

2004

Volume

44

Start / End Page

297 / 323

Location

United States

Related Subject Headings

  • Thermogenesis
  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Pharmacology & Pharmacy
  • Obesity
  • Lipolysis
  • Humans
  • Energy Metabolism
  • Animals
  • Adipose Tissue