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Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism.

Publication ,  Journal Article
Collins, S; Cao, W; Robidoux, J
Published in: Mol Endocrinol
September 2004

The three beta AR (beta-adrenergic receptor) subtypes (beta(1)AR, beta(2)AR, and beta(3)AR) are members of the large family of G protein-coupled receptors, each of which is coupled to G alpha s and increases in intracellular cAMP levels. In white adipose tissues, catecholamine activation of the beta ARs leads to the mobilization of stored fatty acids and regulates release of several adipokines, whereas in brown adipose tissue they stimulate the specialized process of adaptive nonshivering thermogenesis. Noteworthy, in most models of obesity the beta AR system is dysfunctional, and its ability to stimulate lipolysis and thermogenesis are both impaired. Nevertheless, selective agonists for the beta(3)AR, a subtype that is found predominantly in adipocytes, have been able to prevent or reverse obesity and accompanying insulin resistance in animal models. Whether this is a viable therapeutic option for human obesity is much debated with regard to the existence of brown adipocytes in humans or their ability to be recruited. Nevertheless, probing the physiological changes in adrenoceptor function in rodent obesity, as well as the process by which beta(3)AR agonists promote a thermogenic shift in fuel use, have yielded unexpected new insights into beta AR signaling and adipocyte physiology. These include the recent discovery of an essential role of p38 MAPK in mediating adaptive thermogenesis, as well as the accessory role of the ERK MAPK pathway for the control of lipolysis. Because these metabolic events were traditionally ascribed solely to the cAMP/protein kinase A system, the integration of these signaling mechanisms may pose new therapeutic directions in the quest to counter the obesity epidemic in our midst.

Duke Scholars

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Published In

Mol Endocrinol

DOI

ISSN

0888-8809

Publication Date

September 2004

Volume

18

Issue

9

Start / End Page

2123 / 2131

Location

United States

Related Subject Headings

  • Uncoupling Protein 1
  • Transcription, Genetic
  • Thermogenesis
  • Sympathetic Nervous System
  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Promoter Regions, Genetic
  • Molecular Sequence Data
  • Mitogen-Activated Protein Kinases
  • Mitochondrial Proteins
 

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Collins, S., Cao, W., & Robidoux, J. (2004). Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism. Mol Endocrinol, 18(9), 2123–2131. https://doi.org/10.1210/me.2004-0193
Collins, Sheila, Wenhong Cao, and Jacques Robidoux. “Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism.Mol Endocrinol 18, no. 9 (September 2004): 2123–31. https://doi.org/10.1210/me.2004-0193.
Collins, Sheila, et al. “Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism.Mol Endocrinol, vol. 18, no. 9, Sept. 2004, pp. 2123–31. Pubmed, doi:10.1210/me.2004-0193.

Published In

Mol Endocrinol

DOI

ISSN

0888-8809

Publication Date

September 2004

Volume

18

Issue

9

Start / End Page

2123 / 2131

Location

United States

Related Subject Headings

  • Uncoupling Protein 1
  • Transcription, Genetic
  • Thermogenesis
  • Sympathetic Nervous System
  • Signal Transduction
  • Receptors, Adrenergic, beta
  • Promoter Regions, Genetic
  • Molecular Sequence Data
  • Mitogen-Activated Protein Kinases
  • Mitochondrial Proteins