Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics.

Journal Article (Journal Article;Review)

The development of the metabolic syndrome in an increasing percentage of the populations of Western societies, particularly in the United States, requires valid models for establishing basic biochemical changes and performing preclinical studies on potential drug targets. The C57BL/6J mouse has become an important model for understanding the interplay between genetic background and environmental challenges such as high-fat/high-calorie diets that predispose to the development of the metabolic syndrome. This review highlights metabolic and signal transduction features that are altered during the course of disease progression, many of which mirror the human situation.

Full Text

Duke Authors

Cited Authors

  • Collins, S; Martin, TL; Surwit, RS; Robidoux, J

Published Date

  • April 2004

Published In

Volume / Issue

  • 81 / 2

Start / End Page

  • 243 - 248

PubMed ID

  • 15159170

International Standard Serial Number (ISSN)

  • 0031-9384

Digital Object Identifier (DOI)

  • 10.1016/j.physbeh.2004.02.006


  • eng

Conference Location

  • United States