Massive pulmonary edema and death after prostacyclin infusion in a patient with pulmonary veno-occlusive disease.
Journal Article (Journal Article)
Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension associated with fibrotic occlusion of the smaller pulmonary veins. Although vasodilator therapy is effective in many patients with primary pulmonary hypertension, the role of vasodilators in PVOD is unclear because of concerns about precipitating pulmonary edema. Recently, however, there have been reports of successful therapy with oral vasodilators or intravenous administration of prostacyclin in patients with PVOD. In contrast, a patient with PVOD is described who developed acute pulmonary edema and respiratory failure during low-dose prostacyclin infusion, leading to death. This report suggests that vasodilators, especially prostacyclin, must be used with extreme caution in patients with known PVOD.
Full Text
Duke Authors
Cited Authors
- Palmer, SM; Robinson, LJ; Wang, A; Gossage, JR; Bashore, T; Tapson, VF
Published Date
- January 1998
Published In
Volume / Issue
- 113 / 1
Start / End Page
- 237 - 240
PubMed ID
- 9440597
International Standard Serial Number (ISSN)
- 0012-3692
Digital Object Identifier (DOI)
- 10.1378/chest.113.1.237
Language
- eng
Conference Location
- United States