Massive pulmonary edema and death after prostacyclin infusion in a patient with pulmonary veno-occlusive disease.

Journal Article (Journal Article)

Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension associated with fibrotic occlusion of the smaller pulmonary veins. Although vasodilator therapy is effective in many patients with primary pulmonary hypertension, the role of vasodilators in PVOD is unclear because of concerns about precipitating pulmonary edema. Recently, however, there have been reports of successful therapy with oral vasodilators or intravenous administration of prostacyclin in patients with PVOD. In contrast, a patient with PVOD is described who developed acute pulmonary edema and respiratory failure during low-dose prostacyclin infusion, leading to death. This report suggests that vasodilators, especially prostacyclin, must be used with extreme caution in patients with known PVOD.

Full Text

Duke Authors

Cited Authors

  • Palmer, SM; Robinson, LJ; Wang, A; Gossage, JR; Bashore, T; Tapson, VF

Published Date

  • January 1998

Published In

Volume / Issue

  • 113 / 1

Start / End Page

  • 237 - 240

PubMed ID

  • 9440597

International Standard Serial Number (ISSN)

  • 0012-3692

Digital Object Identifier (DOI)

  • 10.1378/chest.113.1.237


  • eng

Conference Location

  • United States