Maternal serum granulocyte-colony stimulating factor in preterm birth with subclinical chorioamnionitis.


Journal Article

Preterm birth has been linked with intrauterine infection and inflammation. Serum and amniotic fluid markers of inflammation, such as interleukin-1 (IL-1), IL-6, and granulocyte-colony stimulating factor (G-CSF), have been associated with clinical chorioamnionitis and preterm delivery. As G-CSF regulates the production and maturation of neutrophils, we sought to determine if maternal serum G-CSF levels are elevated in patients with preterm birth with subclinical histologic chorioamnionitis. Maternal serum G-CSF levels were significantly different among five groups of women studied (P < .001, Kruskall-Wallis test), and were highest in subjects with preterm labor who delivered preterm (P < .05, Mann-Whitney U test). Among women with preterm labor who delivered preterm, maternal serum G-CSF levels were significantly higher if histologic chorioamnionitis was present than when histologic evidence of infection was not present (P = 0.04, Mann-Whitney U test). Intrauterine infection may cause a local inflammatory process and initiate preterm labor. This inflammatory response may include production of G-CSF, which would enter the circulation and stimulate the migration of neutrophils to the site of infection. Our data support this concept, as maternal serum G-CSF is elevated with subclinical infection in association with preterm birth.

Full Text

Cited Authors

  • Boggess, KA; Greig, PC; Murtha, AP; Jimmerson, CE; Herbert, WN

Published Date

  • April 1997

Published In

Volume / Issue

  • 33 / 1

Start / End Page

  • 45 - 52

PubMed ID

  • 9185076

Pubmed Central ID

  • 9185076

Electronic International Standard Serial Number (EISSN)

  • 1872-7603

International Standard Serial Number (ISSN)

  • 0165-0378

Digital Object Identifier (DOI)

  • 10.1016/s0165-0378(97)01011-5


  • eng