Clinical and biochemical presentation of gouty diathesis: comparison of uric acid versus pure calcium stone formation.


Journal Article

We compared gouty diathesis with uric acid versus calcium stones.We retrospectively reviewed clinical and laboratory data from 95 gouty diathesis patients (28 with uric acid and 67 with calcium stones) and 99 normal subjects.Of the gouty diathesis patients gouty arthritis was present in 21% of those with uric acid and 12% of those with calcium stones. Hyperuricemia developed in 43% of those with uric acid and 27% of those with calcium stones, and 2% of controls. Urinary pH was independent of the net gastrointestinal absorption of alkali in the gouty diathesis groups. Urinary pH and citrate increased after potassium citrate treatment.The characteristic features of primary gout were present in both gouty diathesis groups and both are responsive to treatment.

Full Text

Duke Authors

Cited Authors

  • Khatchadourian, J; Preminger, GM; Whitson, PA; Adams-Huet, B; Pak, CY

Published Date

  • November 1995

Published In

Volume / Issue

  • 154 / 5

Start / End Page

  • 1665 - 1669

PubMed ID

  • 7563316

Pubmed Central ID

  • 7563316

Electronic International Standard Serial Number (EISSN)

  • 1527-3792

International Standard Serial Number (ISSN)

  • 0022-5347

Digital Object Identifier (DOI)

  • 10.1016/s0022-5347(01)66743-0


  • eng