Clinical and biochemical presentation of gouty diathesis: comparison of uric acid versus pure calcium stone formation.

Journal Article (Journal Article)

PURPOSE: We compared gouty diathesis with uric acid versus calcium stones. MATERIALS AND METHODS: We retrospectively reviewed clinical and laboratory data from 95 gouty diathesis patients (28 with uric acid and 67 with calcium stones) and 99 normal subjects. RESULTS: Of the gouty diathesis patients gouty arthritis was present in 21% of those with uric acid and 12% of those with calcium stones. Hyperuricemia developed in 43% of those with uric acid and 27% of those with calcium stones, and 2% of controls. Urinary pH was independent of the net gastrointestinal absorption of alkali in the gouty diathesis groups. Urinary pH and citrate increased after potassium citrate treatment. CONCLUSIONS: The characteristic features of primary gout were present in both gouty diathesis groups and both are responsive to treatment.

Full Text

Duke Authors

Cited Authors

  • Khatchadourian, J; Preminger, GM; Whitson, PA; Adams-Huet, B; Pak, CY

Published Date

  • November 1995

Published In

Volume / Issue

  • 154 / 5

Start / End Page

  • 1665 - 1669

PubMed ID

  • 7563316

International Standard Serial Number (ISSN)

  • 0022-5347

Digital Object Identifier (DOI)

  • 10.1016/s0022-5347(01)66743-0


  • eng

Conference Location

  • United States