Clinical and biochemical presentation of gouty diathesis: comparison of uric acid versus pure calcium stone formation.


Journal Article

PURPOSE:We compared gouty diathesis with uric acid versus calcium stones. MATERIALS AND METHODS:We retrospectively reviewed clinical and laboratory data from 95 gouty diathesis patients (28 with uric acid and 67 with calcium stones) and 99 normal subjects. RESULTS:Of the gouty diathesis patients gouty arthritis was present in 21% of those with uric acid and 12% of those with calcium stones. Hyperuricemia developed in 43% of those with uric acid and 27% of those with calcium stones, and 2% of controls. Urinary pH was independent of the net gastrointestinal absorption of alkali in the gouty diathesis groups. Urinary pH and citrate increased after potassium citrate treatment. CONCLUSIONS:The characteristic features of primary gout were present in both gouty diathesis groups and both are responsive to treatment.

Full Text

Duke Authors

Cited Authors

  • Khatchadourian, J; Preminger, GM; Whitson, PA; Adams-Huet, B; Pak, CY

Published Date

  • November 1995

Published In

Volume / Issue

  • 154 / 5

Start / End Page

  • 1665 - 1669

PubMed ID

  • 7563316

Pubmed Central ID

  • 7563316

Electronic International Standard Serial Number (EISSN)

  • 1527-3792

International Standard Serial Number (ISSN)

  • 0022-5347

Digital Object Identifier (DOI)

  • 10.1097/00005392-199511000-00014


  • eng