Primary intraocular T-cell-rich large B-cell lymphoma.

Published

Journal Article

We report a primary intraocular T-cell-rich large B-cell lymphoma in a 57-year-old woman who underwent 3 diagnostic vitrectomies for a presumed diagnosis of panuveitis. She developed no light perception in the left eye and underwent enucleation. Histopathologic and immunohistochemical studies on the enucleated globe disclosed a primary intraocular large B-cell lymphoma involving the choroid, vitreous, and retina. A large population of T cells was identified among the neoplastic B-cell population. B-cell immunoglobulin gene rearrangement and T-cell receptor gene rearrangement studies using the polymerase chain reaction method indicated that a monoclonal immunoglobulin kappa light chain population was present and that the T-cell population was not monoclonal. This case highlights the importance of interpreting cytologic features in vitreous aspirates in the context of the clinical situation.

Full Text

Duke Authors

Cited Authors

  • Cummings, TJ; Stenzel, TT; Klintworth, G; Jaffe, GJ

Published Date

  • August 2005

Published In

Volume / Issue

  • 129 / 8

Start / End Page

  • 1050 - 1053

PubMed ID

  • 16048400

Pubmed Central ID

  • 16048400

Electronic International Standard Serial Number (EISSN)

  • 1543-2165

International Standard Serial Number (ISSN)

  • 0003-9985

Digital Object Identifier (DOI)

  • 10.1043/1543-2165(2005)129[1050:pitlbl]2.0.co;2

Language

  • eng