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Detection of broadly expressed neuronal genes in C. elegans.

Publication ,  Journal Article
Ruvinsky, I; Ohler, U; Burge, CB; Ruvkun, G
Published in: Dev Biol
February 15, 2007

The genes that are expressed in most or all types of neurons define generic neuronal features and provide a window into the developmental origin and function of the nervous system. Few such genes (sometimes referred to as pan-neuronal or broadly expressed neuronal genes) have been defined to date and the mechanisms controlling their regulation are not well understood. As a first step in investigating their regulation, we used a computational approach to detect sequences overrepresented in their promoter elements. We identified a ten-nucleotide cis-regulatory motif shared by many broadly expressed neuronal genes and demonstrated that it is involved in control of neuronal expression. Our results further suggest that global and cell-type-specific controls likely act in concert to establish pan-neuronal gene expression. Using the newly discovered motif and genome-level gene expression data, we identified a set of 234 candidate broadly expressed genes. The known involvement of many of these genes in neurogenesis and physiology of the nervous system supports the utility of this set for future targeted analyses.

Duke Scholars

Published In

Dev Biol

DOI

ISSN

0012-1606

Publication Date

February 15, 2007

Volume

302

Issue

2

Start / End Page

617 / 626

Location

United States

Related Subject Headings

  • Promoter Regions, Genetic
  • Neurons
  • Genome, Helminth
  • Gene Expression Profiling
  • Developmental Biology
  • Caenorhabditis elegans Proteins
  • Caenorhabditis elegans
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
 

Citation

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Ruvinsky, I., Ohler, U., Burge, C. B., & Ruvkun, G. (2007). Detection of broadly expressed neuronal genes in C. elegans. Dev Biol, 302(2), 617–626. https://doi.org/10.1016/j.ydbio.2006.09.014
Ruvinsky, Ilya, Uwe Ohler, Christopher B. Burge, and Gary Ruvkun. “Detection of broadly expressed neuronal genes in C. elegans.Dev Biol 302, no. 2 (February 15, 2007): 617–26. https://doi.org/10.1016/j.ydbio.2006.09.014.
Ruvinsky I, Ohler U, Burge CB, Ruvkun G. Detection of broadly expressed neuronal genes in C. elegans. Dev Biol. 2007 Feb 15;302(2):617–26.
Ruvinsky, Ilya, et al. “Detection of broadly expressed neuronal genes in C. elegans.Dev Biol, vol. 302, no. 2, Feb. 2007, pp. 617–26. Pubmed, doi:10.1016/j.ydbio.2006.09.014.
Ruvinsky I, Ohler U, Burge CB, Ruvkun G. Detection of broadly expressed neuronal genes in C. elegans. Dev Biol. 2007 Feb 15;302(2):617–626.
Journal cover image

Published In

Dev Biol

DOI

ISSN

0012-1606

Publication Date

February 15, 2007

Volume

302

Issue

2

Start / End Page

617 / 626

Location

United States

Related Subject Headings

  • Promoter Regions, Genetic
  • Neurons
  • Genome, Helminth
  • Gene Expression Profiling
  • Developmental Biology
  • Caenorhabditis elegans Proteins
  • Caenorhabditis elegans
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences