High-density mapping of chromosomal arm 1q in renal collecting duct carcinoma: region of minimal deletion at 1q32.1-32.2.

Journal Article (Journal Article)

Collecting duct carcinoma (CDC) of the kidney is a rare malignant neoplasm of distal nephron origin. Previous studies of CDC have shown loss of heterozygosity on chromosomal arm 1q in 57% of the cases studied. To better characterize 1q loss in CDC, we performed high-density mapping of the entire long arm of chromosome 1 in 13 CDC tumor samples. We observed complete deletion of chromosomal arm 1q in 5 samples and partial deletion in 4 additional tumors. Our study further showed that the region of minimal deletion is located at 1q32.1-32.2. Sixty-nine percent (9 of 13) of the tumors showed loss of heterozygosity in this area. These data suggest that a gene or group of genes that contribute to the development of distal nephron tumors may be located within the 1q32.1-32.2 region.

Full Text

Duke Authors

Cited Authors

  • Steiner, G; Cairns, P; Polascik, TJ; Marshall, FF; Epstein, JI; Sidransky, D; Schoenberg, M

Published Date

  • November 1, 1996

Published In

Volume / Issue

  • 56 / 21

Start / End Page

  • 5044 - 5046

PubMed ID

  • 8895762

International Standard Serial Number (ISSN)

  • 0008-5472


  • eng

Conference Location

  • United States