Frequency of homozygous deletion at p16/CDKN2 in primary human tumours.

Journal Article (Journal Article)

Many tumour types have been reported to have deletion of 9p21 (refs 1-6). A candidate target suppressor gene, p16 (p16INK4a/MTS-1/CDKN2), was recently identified within the commonly deleted region in tumour cell lines. An increasing and sometimes conflicting body of data has accumulated regarding the frequency of homozygous deletion and the importance of p16 in primary tumours. We tested 545 primary tumours by microsatellite analysis with existing and newly cloned markers around the p16 locus. We have now found that small homozygous deletions represent the predominant mechanism of inactivation at 9p21 in bladder tumours and are present in other tumour types, including breast and prostate cancer. Moreover, fine mapping of these deletions implicates a 170 kb minimal region that includes p16 and excludes p15.

Full Text

Duke Authors

Cited Authors

  • Cairns, P; Polascik, TJ; Eby, Y; Tokino, K; Califano, J; Merlo, A; Mao, L; Herath, J; Jenkins, R; Westra, W; Rutter, JL; Buckler, A; Gabrielson, E; Tockman, M; Cho, KR; Hedrick, L; Bova, GS; Isaacs, W; Koch, W; Schwab, D; Sidransky, D

Published Date

  • October 1995

Published In

Volume / Issue

  • 11 / 2

Start / End Page

  • 210 - 212

PubMed ID

  • 7550353

International Standard Serial Number (ISSN)

  • 1061-4036

Digital Object Identifier (DOI)

  • 10.1038/ng1095-210


  • eng

Conference Location

  • United States