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Update on cryotherapy for prostate cancer in 2006.

Publication ,  Journal Article
Mouraviev, V; Polascik, TJ
Published in: Curr Opin Urol
May 2006

PURPOSE OF REVIEW: With the recent introduction of novel, minimally invasive procedures for the treatment of prostate cancer, cryotherapy has become a feasible option as a viable alternative to traditional radical surgery and radiation therapy. In this review we update recent data concerning the basic science of cryobiology, technical trends, oncologic results and complications of this procedure. RECENT FINDINGS: As a result of better understanding of tumor cryodestruction at a molecular level, refinements in cryotechniques and improved patient selection, the results of cryotherapy are becoming more promising. Furthermore, the dramatic decrease in the number of complications after modern cryotherapy leads to a better quality of life, which may be a preferable option, especially for elderly patients with comorbidities. Current trends towards nerve-sparing and focal cryoablation are also discussed. Recent advances in cryobiology open up new opportunities to apply cryotherapy in combination with chemotherapy or radiotherapy for patients with intermediate or high-risk cancers. SUMMARY: Potential directions for future developments in cryosurgery include concepts to reduce side effects such as minimizing cryodamage of the neurovascular bundles (nerve-sparing procedure), and focal ablation of a specific tumor site in patients in whom saturation biopsy supports unifocal prostate cancer.

Duke Scholars

Published In

Curr Opin Urol

DOI

ISSN

0963-0643

Publication Date

May 2006

Volume

16

Issue

3

Start / End Page

152 / 156

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Salvage Therapy
  • Prostatic Neoplasms
  • Postoperative Complications
  • Male
  • Humans
  • Cryosurgery
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
 

Citation

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Mouraviev, V., & Polascik, T. J. (2006). Update on cryotherapy for prostate cancer in 2006. Curr Opin Urol, 16(3), 152–156. https://doi.org/10.1097/01.mou.0000193393.54598.9f
Mouraviev, Vladimir, and Thomas J. Polascik. “Update on cryotherapy for prostate cancer in 2006.Curr Opin Urol 16, no. 3 (May 2006): 152–56. https://doi.org/10.1097/01.mou.0000193393.54598.9f.
Mouraviev V, Polascik TJ. Update on cryotherapy for prostate cancer in 2006. Curr Opin Urol. 2006 May;16(3):152–6.
Mouraviev, Vladimir, and Thomas J. Polascik. “Update on cryotherapy for prostate cancer in 2006.Curr Opin Urol, vol. 16, no. 3, May 2006, pp. 152–56. Pubmed, doi:10.1097/01.mou.0000193393.54598.9f.
Mouraviev V, Polascik TJ. Update on cryotherapy for prostate cancer in 2006. Curr Opin Urol. 2006 May;16(3):152–156.

Published In

Curr Opin Urol

DOI

ISSN

0963-0643

Publication Date

May 2006

Volume

16

Issue

3

Start / End Page

152 / 156

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Salvage Therapy
  • Prostatic Neoplasms
  • Postoperative Complications
  • Male
  • Humans
  • Cryosurgery
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services