Neuropsychiatric complications after temporal lobe limbic system surgery.

Published

Journal Article (Review)

Although control of seizure activity is the main goal of temporal lobectomies for complex partial epilepsy, the results of surgery must be viewed within the larger context of possible ramifications of limbic system disruption. The neuropsychiatric complications may be significant and influence the patient's perceived qualify of life, thus detracting from the benefits of seizure control. It is apparent from the previous studies that the modalities affected are influenced by the laterality of the resection, with left-sided lobectomies more often affecting verbal memory and learning, whereas right-sided resections may cause visual/spatial memory and cognitive declines. Preoperative neuropsychologic testing may help to predict these possible complications. General psychosocial function, memory, and cognition all seem to be less affected when complete seizure control is attained, with nearly 80% experiencing no significant change in neuropsychologic testing and the gain and losses being equal in magnitude. Also, younger patients and those with a shorter history of seizure activity may fare better after surgery because of a greater capacity for neuronal plasticity to subserve these functions. These findings support the contention that early diagnosis and surgical treatment may help to minimize potential neuropsychiatric complications in conjunction with improved postoperative seizure control.

Full Text

Duke Authors

Cited Authors

  • Gabriel, EM; Haglund, MM

Published Date

  • February 1997

Published In

Volume / Issue

  • 7 / 1

Start / End Page

  • 155 - 164

PubMed ID

  • 9100236

Pubmed Central ID

  • 9100236

Electronic International Standard Serial Number (EISSN)

  • 1557-9867

International Standard Serial Number (ISSN)

  • 1052-5149

Language

  • eng