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Enhanced optical imaging of rat gliomas and tumor margins.

Publication ,  Journal Article
Haglund, MM; Hochman, DW; Spence, AM; Berger, MS
Published in: Neurosurgery
November 1994

Current intraoperative methods used to maximize the extent of tumor removal are limited to intraoperative biopsies, ultrasound, and stereotactic volumetric resections. A new technique involving the optical imaging of an intravenously injected dye has the potential to localize tumors and their margins with a high degree of accuracy. In a rat glioma model, enhanced optical imaging was performed and indocyanine green was used as the contrast-enhancing agent. In all 22 animals, the peak optical change in the tumor was greater than in the ipsilateral brain around the tumor and the contralateral normal hemisphere. The clearance of the dye was significantly delayed to a greater extent in the tumor than in the brain around the tumor and the normal brain. After attempts were made at complete microscopic resection, enhanced optical imaging of the tumor margins and the histological samples demonstrated a specificity of 93% and a sensitivity of 89.5%. Enhanced optical imaging was capable of outlining the tumor even when the imaging was done through the cranium. The optical imaging of rat gliomas with a contrast-enhancing dye is able to differentiate between normal brain and tumor tissue both at the cortical surface and at the tumor margins. The application of these studies in an intraoperative clinical setting may allow for the more accurate determination of tumor margins and may increase the extent of tumor removal.

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Published In

Neurosurgery

DOI

ISSN

0148-396X

Publication Date

November 1994

Volume

35

Issue

5

Start / End Page

930 / 940

Location

United States

Related Subject Headings

  • Rats, Inbred F344
  • Rats
  • Neurology & Neurosurgery
  • Neoplasm, Residual
  • Neoplasm Transplantation
  • Microsurgery
  • Indocyanine Green
  • Image Processing, Computer-Assisted
  • Image Enhancement
  • Frontal Lobe
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Haglund, M. M., Hochman, D. W., Spence, A. M., & Berger, M. S. (1994). Enhanced optical imaging of rat gliomas and tumor margins. Neurosurgery, 35(5), 930–940. https://doi.org/10.1227/00006123-199411000-00019
Haglund, M. M., D. W. Hochman, A. M. Spence, and M. S. Berger. “Enhanced optical imaging of rat gliomas and tumor margins.Neurosurgery 35, no. 5 (November 1994): 930–40. https://doi.org/10.1227/00006123-199411000-00019.
Haglund MM, Hochman DW, Spence AM, Berger MS. Enhanced optical imaging of rat gliomas and tumor margins. Neurosurgery. 1994 Nov;35(5):930–40.
Haglund, M. M., et al. “Enhanced optical imaging of rat gliomas and tumor margins.Neurosurgery, vol. 35, no. 5, Nov. 1994, pp. 930–40. Pubmed, doi:10.1227/00006123-199411000-00019.
Haglund MM, Hochman DW, Spence AM, Berger MS. Enhanced optical imaging of rat gliomas and tumor margins. Neurosurgery. 1994 Nov;35(5):930–940.
Journal cover image

Published In

Neurosurgery

DOI

ISSN

0148-396X

Publication Date

November 1994

Volume

35

Issue

5

Start / End Page

930 / 940

Location

United States

Related Subject Headings

  • Rats, Inbred F344
  • Rats
  • Neurology & Neurosurgery
  • Neoplasm, Residual
  • Neoplasm Transplantation
  • Microsurgery
  • Indocyanine Green
  • Image Processing, Computer-Assisted
  • Image Enhancement
  • Frontal Lobe