Developmental and regional differences in the localization of Na,K-ATPase activity in the rabbit hippocampus.


Journal Article

Regional differences in Na,K-ATPase activity, and development of Na,K-ATPase activity were examined in rabbit hippocampus using a histochemical marker of enzyme activity. Stratum lucidum of CA3/CA2, corresponding to the mossy fiber terminal field, showed high Na,K-ATPase activity compared to stratum radiatum of CA1. A significant increase in Na,K-ATPase activity was found between 8 and 15 days postnatal. Tissues with limited Na,K-ATPase activity (immature hippocampus, the mature CA1 region) appear particularly prone to seizure-like abnormalities, perhaps reflecting an inability to regulate extracellular potassium.

Full Text

Duke Authors

Cited Authors

  • Haglund, MM; Stahl, WL; Kunkel, DD; Schwartzkroin, PA

Published Date

  • September 16, 1985

Published In

Volume / Issue

  • 343 / 1

Start / End Page

  • 198 - 203

PubMed ID

  • 2994829

Pubmed Central ID

  • 2994829

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(85)91180-1


  • eng

Conference Location

  • Netherlands