Pulmonary function abnormalities in long-term survivors of childhood cancer.

Journal Article (Journal Article)

Pulmonary function testing (PFT) was performed on 29 long-term survivors of childhood cancer. The patients, whose mean age was 11.7 years and whose mean age at diagnosis was 3.7 years, included 12 females and 17 males. Original diagnoses included 15 patients with leukemia and 14 individuals with solid tumors. Nine patients had received cyclophosphamide and 20 had received radiation therapy. Included in this latter group were five patients who had received radiation therapy to the thorax. Eight patients had acquired pneumonia during their treatment. Physical examination was normal in all the patients, and none had a history of acute or chronic pulmonary disease. PFT demonstrated an incidence of abnormalities in forced vital capacity (FVC) and/or total lung capacity (TLC) in 48% of the patients. Patients who were under 3 years of age at the time of diagnosis or who had received radiation to the thorax were more likely to demonstrate PFT abnormalities, but these differences did not reach statistical significance. The natural history of pulmonary function and subsequent respiratory disease in survivors of childhood cancer requires further definition.

Full Text

Duke Authors

Cited Authors

  • Miller, RW; Fusner, JE; Fink, RJ; Murphy, TM; Getson, PR; Vojtova, JA; Reaman, GH

Published Date

  • 1986

Published In

Volume / Issue

  • 14 / 4

Start / End Page

  • 202 - 207

PubMed ID

  • 3747939

Pubmed Central ID

  • 3747939

International Standard Serial Number (ISSN)

  • 0098-1532

Digital Object Identifier (DOI)

  • 10.1002/mpo.2950140403


  • eng

Conference Location

  • United States