On the terminology for describing the length-force relationship and its changes in airway smooth muscle.

Published

Journal Article (Review)

The observation that the length-force relationship in airway smooth muscle can be shifted along the length axis by accommodating the muscle at different lengths has stimulated great interest. In light of the recent understanding of the dynamic nature of length-force relationship, many of our concepts regarding smooth muscle mechanical properties, including the notion that the muscle possesses a unique optimal length that correlates to maximal force generation, are likely to be incorrect. To facilitate accurate and efficient communication among scientists interested in the function of airway smooth muscle, a revised and collectively accepted nomenclature describing the adaptive and dynamic nature of the length-force relationship will be invaluable. Setting aside the issue of underlying mechanism, the purpose of this article is to define terminology that will aid investigators in describing observed phenomena. In particular, we recommend that the term "optimal length" (or any other term implying a unique length that correlates with maximal force generation) for airway smooth muscle be avoided. Instead, the in situ length or an arbitrary but clearly defined reference length should be used. We propose the usage of "length adaptation" to describe the phenomenon whereby the length-force curve of a muscle shifts along the length axis due to accommodation of the muscle at different lengths. We also discuss frequently used terms that do not have commonly accepted definitions that should be used cautiously.

Full Text

Duke Authors

Cited Authors

  • Bai, TR; Bates, JHT; Brusasco, V; Camoretti-Mercado, B; Chitano, P; Deng, LH; Dowell, M; Fabry, B; Ford, LE; Fredberg, JJ; Gerthoffer, WT; Gilbert, SH; Gunst, SJ; Hai, C-M; Halayko, AJ; Hirst, SJ; James, AL; Janssen, LJ; Jones, KA; King, GG; Lakser, OJ; Lambert, RK; Lauzon, A-M; Lutchen, KR; Maksym, GN; Meiss, RA; Mijailovich, SM; Mitchell, HW; Mitchell, RW; Mitzner, W; Murphy, TM; Paré, PD; Schellenberg, RR; Seow, CY; Sieck, GC; Smith, PG; Smolensky, AV; Solway, J; Stephens, NL; Stewart, AG; Tang, DD; Wang, L

Published Date

  • December 2004

Published In

Volume / Issue

  • 97 / 6

Start / End Page

  • 2029 - 2034

PubMed ID

  • 15531570

Pubmed Central ID

  • 15531570

Electronic International Standard Serial Number (EISSN)

  • 1522-1601

International Standard Serial Number (ISSN)

  • 8750-7587

Digital Object Identifier (DOI)

  • 10.1152/japplphysiol.00884.2004

Language

  • eng