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Cowpox virus and other members of the orthopoxvirus genus interfere with the regulation of NF-kappaB activation.

Publication ,  Journal Article
Oie, KL; Pickup, DJ
Published in: Virology
September 15, 2001

NF-kappaB comprises a family of transcription factors that regulate key immune processes. In this study, the effects of orthopoxvirus infection upon the activation of NF-kappaB were examined. During the early phase of infection, cowpox virus can inhibit the induction of NF-kappaB-regulated gene expression by interfering with the process of IkappaBalpha degradation. Although either okadaic acid or tumor necrosis factor (TNF) treatment of infected cells can induce IkappaBalpha phosphorylation, further processing of IkappaBalpha is inhibited. These results suggest that cowpox virus is capable of inhibiting the activation of NF-kappaB at a point where multiple signal transduction pathways converge. Other orthopoxviruses affect NF-kappaB activity, but in a type-specific manner. Raccoonpox virus and vaccinia virus (Copenhagen strain) negatively affect NF-kappaB induction by TNF. In contrast, the modified vaccinia virus Ankara strain induces NF-kappaB activation, even in the absence of other stimuli. These findings suggest that orthopoxviruses may affect a broad range of virus-host interactions through their effects upon NF-kappaB activation. Moreover, because of the central role for NF-kappaB in immune processes and disease, these type-specific effects may contribute significantly to the immunogenic and pathogenic properties of poxviruses.

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Published In

Virology

DOI

ISSN

0042-6822

Publication Date

September 15, 2001

Volume

288

Issue

1

Start / End Page

175 / 187

Location

United States

Related Subject Headings

  • Virology
  • Vaccinia virus
  • Tumor Necrosis Factor-alpha
  • Tumor Cells, Cultured
  • Raccoons
  • Phosphorylation
  • Osteosarcoma
  • Orthopoxvirus
  • Okadaic Acid
  • NF-kappa B
 

Citation

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Oie, K. L., & Pickup, D. J. (2001). Cowpox virus and other members of the orthopoxvirus genus interfere with the regulation of NF-kappaB activation. Virology, 288(1), 175–187. https://doi.org/10.1006/viro.2001.1090
Oie, K. L., and D. J. Pickup. “Cowpox virus and other members of the orthopoxvirus genus interfere with the regulation of NF-kappaB activation.Virology 288, no. 1 (September 15, 2001): 175–87. https://doi.org/10.1006/viro.2001.1090.
Oie, K. L., and D. J. Pickup. “Cowpox virus and other members of the orthopoxvirus genus interfere with the regulation of NF-kappaB activation.Virology, vol. 288, no. 1, Sept. 2001, pp. 175–87. Pubmed, doi:10.1006/viro.2001.1090.
Journal cover image

Published In

Virology

DOI

ISSN

0042-6822

Publication Date

September 15, 2001

Volume

288

Issue

1

Start / End Page

175 / 187

Location

United States

Related Subject Headings

  • Virology
  • Vaccinia virus
  • Tumor Necrosis Factor-alpha
  • Tumor Cells, Cultured
  • Raccoons
  • Phosphorylation
  • Osteosarcoma
  • Orthopoxvirus
  • Okadaic Acid
  • NF-kappa B