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Transcription of orthopoxvirus telomeres at late times during infection.

Publication ,  Journal Article
Parsons, BL; Pickup, DJ
Published in: Virology
March 1990

The telomeres of orthopoxvirus DNAs consists largely of short repeated sequences organized into at least two separate sets. Although the sequence composition of the orthopoxvirus telomeres is highly conserved, these regions do not appear to encode any proteins. At late times during infection, the telomeres of vaccinia virus are transcribed. A promoter in the region between the two sets of repeats directs transcription towards the hairpin-loop end of the viral DNA. This promoter resembles the promoters of other poxvirus late genes, and directs the synthesis of RNAs whose structure is consistent with the presence of 5' poly(A) sequences typical of late RNAs. The lengths of these late transcripts suggest that some transcription extends through the hairpin-loop region. This might occur either when the genome is in a monomeric form or when the genome is in the concatemeric form of the DNA replication intermediate. The function of late transcription of the telomeres is unclear, but similar transcription of the telomeres of vaccinia virus, cowpox virus, and raccoonpox virus suggests that such transcription may have a role in viral replication.

Duke Scholars

Published In

Virology

DOI

ISSN

0042-6822

Publication Date

March 1990

Volume

175

Issue

1

Start / End Page

69 / 80

Location

United States

Related Subject Headings

  • Virology
  • Transcription, Genetic
  • Single-Strand Specific DNA and RNA Endonucleases
  • Sequence Homology, Nucleic Acid
  • Restriction Mapping
  • RNA, Viral
  • RNA, Messenger
  • RNA Probes
  • Promoter Regions, Genetic
  • Poxviridae
 

Citation

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Parsons, B. L., & Pickup, D. J. (1990). Transcription of orthopoxvirus telomeres at late times during infection. Virology, 175(1), 69–80. https://doi.org/10.1016/0042-6822(90)90187-v
Parsons, B. L., and D. J. Pickup. “Transcription of orthopoxvirus telomeres at late times during infection.Virology 175, no. 1 (March 1990): 69–80. https://doi.org/10.1016/0042-6822(90)90187-v.
Parsons BL, Pickup DJ. Transcription of orthopoxvirus telomeres at late times during infection. Virology. 1990 Mar;175(1):69–80.
Parsons, B. L., and D. J. Pickup. “Transcription of orthopoxvirus telomeres at late times during infection.Virology, vol. 175, no. 1, Mar. 1990, pp. 69–80. Pubmed, doi:10.1016/0042-6822(90)90187-v.
Parsons BL, Pickup DJ. Transcription of orthopoxvirus telomeres at late times during infection. Virology. 1990 Mar;175(1):69–80.
Journal cover image

Published In

Virology

DOI

ISSN

0042-6822

Publication Date

March 1990

Volume

175

Issue

1

Start / End Page

69 / 80

Location

United States

Related Subject Headings

  • Virology
  • Transcription, Genetic
  • Single-Strand Specific DNA and RNA Endonucleases
  • Sequence Homology, Nucleic Acid
  • Restriction Mapping
  • RNA, Viral
  • RNA, Messenger
  • RNA Probes
  • Promoter Regions, Genetic
  • Poxviridae