Virulence genes of poxviruses and reoviruses.

Journal Article (Journal Article;Review)

Identification of viral genes that specify virulence, however defined, is of critical importance for the design of viral vaccines. In particular, the targeted development not only of avirulent vaccine strains but also of viruses to be used as carriers for foreign genes depends on the inactivation or deletion of genes that harm the host. This paper illustrates approaches to identifying viral pathogenesis genes in two model systems involving cowpox virus and reovirus, respectively.

Full Text

Duke Authors

Cited Authors

  • Joklik, WK; Pickup, DJ; Patel, DD; Moody, MD

Published Date

  • April 1, 1988

Published In

Volume / Issue

  • 6 / 2

Start / End Page

  • 123 - 128

PubMed ID

  • 2838983

International Standard Serial Number (ISSN)

  • 0264-410X

Digital Object Identifier (DOI)

  • 10.1016/s0264-410x(88)80013-6


  • eng

Conference Location

  • Netherlands