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Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: a soluble, secreted CD30 homologue.

Publication ,  Journal Article
Panus, JF; Smith, CA; Ray, CA; Smith, TD; Patel, DD; Pickup, DJ
Published in: Proc Natl Acad Sci U S A
June 11, 2002

Cowpox virus (Brighton Red strain) possesses one of the largest genomes in the Orthopoxvirus genus. Sequence analysis of a region of the genome that is type-specific for cowpox virus identified a gene, vCD30, encoding a soluble, secreted protein that is the fifth member of the tumor necrosis factor receptor family known to be encoded by cowpox virus. The vCD30 protein contains 110 aa, including a 21-residue signal peptide, a potential O-linked glycosylation site, and a 58-aa sequence sharing 51-59% identity with highly conserved extracellular segments of both mouse and human CD30. A vCD30Fc fusion protein binds CD153 (CD30 ligand) specifically, and it completely inhibits CD153/CD30 interactions. Although the functions of CD30 are not well understood, the existence of vCD30 suggests that the cellular receptor plays a significant role in normal immune responses. Viral inhibition of CD30 also lends support to the potential therapeutic value of targeting CD30 in human inflammatory and autoimmune diseases.

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Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

June 11, 2002

Volume

99

Issue

12

Start / End Page

8348 / 8353

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Transfection
  • Sequence Homology, Amino Acid
  • Sequence Alignment
  • Recombination, Genetic
  • Recombinant Fusion Proteins
  • Receptors, Tumor Necrosis Factor
  • Plasmids
  • Osteosarcoma
  • Molecular Sequence Data
 

Citation

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Panus, J. F., Smith, C. A., Ray, C. A., Smith, T. D., Patel, D. D., & Pickup, D. J. (2002). Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: a soluble, secreted CD30 homologue. Proc Natl Acad Sci U S A, 99(12), 8348–8353. https://doi.org/10.1073/pnas.122238599
Panus, Joanne Fanelli, Craig A. Smith, Caroline A. Ray, Terri Davis Smith, Dhavalkumar D. Patel, and David J. Pickup. “Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: a soluble, secreted CD30 homologue.Proc Natl Acad Sci U S A 99, no. 12 (June 11, 2002): 8348–53. https://doi.org/10.1073/pnas.122238599.
Panus JF, Smith CA, Ray CA, Smith TD, Patel DD, Pickup DJ. Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: a soluble, secreted CD30 homologue. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8348–53.
Panus, Joanne Fanelli, et al. “Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: a soluble, secreted CD30 homologue.Proc Natl Acad Sci U S A, vol. 99, no. 12, June 2002, pp. 8348–53. Pubmed, doi:10.1073/pnas.122238599.
Panus JF, Smith CA, Ray CA, Smith TD, Patel DD, Pickup DJ. Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: a soluble, secreted CD30 homologue. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8348–8353.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

June 11, 2002

Volume

99

Issue

12

Start / End Page

8348 / 8353

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Transfection
  • Sequence Homology, Amino Acid
  • Sequence Alignment
  • Recombination, Genetic
  • Recombinant Fusion Proteins
  • Receptors, Tumor Necrosis Factor
  • Plasmids
  • Osteosarcoma
  • Molecular Sequence Data