Topical thrombin and acquired coagulation factor inhibitors: clinical spectrum and laboratory diagnosis.

Journal Article (Journal Article;Review)

Topical bovine thrombin preparations are used extensively in cardiovascular, neurosurgical, and otolaryngologic procedures. Patients who are treated with these topical thrombin preparations may develop antibodies to bovine coagulation factors that may cross-react with the endogenous human clotting proteins. We have identified four patients with acquired factor inhibitors following exposure to topical thrombin at Duke University Medical Center and summarize these cases in addition to 13 patients previously reported in the literature. In most cases, the inhibitor developed following a second (or subsequent) exposure to topical thrombin. The clinical course was extremely variable, ranging from totally asymptomatic to life-threatening hemorrhage. The most consistent laboratory abnormality was a prolonged bovine thrombin clotting time, which corrected, at least partially, when human thrombin was substituted for bovine thrombin. Some of these patients also developed factor V inhibitors with prolonged prothrombin and activated partial thromboplastin times. Although these patients have prolonged clotting times, they should not be considered "autoanticoagulated," since thromboembolic complications can still occur. Therapeutic intervention is largely empirical and depends on the clinical manifestations of the individual patient.

Full Text

Duke Authors

Cited Authors

  • Ortel, TL; Charles, LA; Keller, FG; Marcom, PK; Oldham, HN; Kane, WH; Macik, BG

Published Date

  • February 1994

Published In

Volume / Issue

  • 45 / 2

Start / End Page

  • 128 - 135

PubMed ID

  • 8141118

International Standard Serial Number (ISSN)

  • 0361-8609

Digital Object Identifier (DOI)

  • 10.1002/ajh.2830450206


  • eng

Conference Location

  • United States