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Idiotypes, anti-idiotypes, and autoimmunity.

Publication ,  Journal Article
Rico, MJ; Hall, RP
Published in: J Am Acad Dermatol
September 1988

Over the past two decades it has become clear that the ability of a host to generate antibodies against a wide variety of potential antigens is due to structural diversity in the antibody molecule within the variable region. This diversity results in sites within the molecule that are themselves immunogenic. These immunogenic sites are called idiotopes, and the collection of idiotopes on a single antibody molecule determines that antibody's idiotype. The idiotype of an antibody molecule is defined serologically by a second antibody termed an anti-idiotype. Anti-idiotypic antibodies can recognize antibody molecules bearing similar or identical structures within the variable regions, which are often on or near sites of antigen binding. Investigation into the nature of idiotype and anti-idiotype interactions has increased our knowledge of antibody structure, antigen-antibody interactions, the regulation of antibody production, and the nature of autoimmune disorders. This review will discuss the nature of idiotypes and anti-idiotypes and their potential role in the diagnosis, management, and treatment of autoimmune, infectious, and malignant diseases.

Duke Scholars

Published In

J Am Acad Dermatol

DOI

ISSN

0190-9622

Publication Date

September 1988

Volume

19

Issue

3

Start / End Page

579 / 585

Location

United States

Related Subject Headings

  • Molecular Structure
  • Immunoglobulin Idiotypes
  • Humans
  • Dermatology & Venereal Diseases
  • Cross Reactions
  • Autoimmune Diseases
  • Antibody Specificity
  • Antibodies, Anti-Idiotypic
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rico, M. J., & Hall, R. P. (1988). Idiotypes, anti-idiotypes, and autoimmunity. J Am Acad Dermatol, 19(3), 579–585. https://doi.org/10.1016/s0190-9622(88)70212-1
Rico, M. J., and R. P. Hall. “Idiotypes, anti-idiotypes, and autoimmunity.J Am Acad Dermatol 19, no. 3 (September 1988): 579–85. https://doi.org/10.1016/s0190-9622(88)70212-1.
Rico MJ, Hall RP. Idiotypes, anti-idiotypes, and autoimmunity. J Am Acad Dermatol. 1988 Sep;19(3):579–85.
Rico, M. J., and R. P. Hall. “Idiotypes, anti-idiotypes, and autoimmunity.J Am Acad Dermatol, vol. 19, no. 3, Sept. 1988, pp. 579–85. Pubmed, doi:10.1016/s0190-9622(88)70212-1.
Rico MJ, Hall RP. Idiotypes, anti-idiotypes, and autoimmunity. J Am Acad Dermatol. 1988 Sep;19(3):579–585.
Journal cover image

Published In

J Am Acad Dermatol

DOI

ISSN

0190-9622

Publication Date

September 1988

Volume

19

Issue

3

Start / End Page

579 / 585

Location

United States

Related Subject Headings

  • Molecular Structure
  • Immunoglobulin Idiotypes
  • Humans
  • Dermatology & Venereal Diseases
  • Cross Reactions
  • Autoimmune Diseases
  • Antibody Specificity
  • Antibodies, Anti-Idiotypic
  • 3202 Clinical sciences
  • 1103 Clinical Sciences