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Expression of interleukin-4 and interferon-gamma in the small bowel of patients with dermatitis herpetiformis and isolated gluten-sensitive enteropathy.

Publication ,  Journal Article
Smith, AD; Bagheri, B; Streilein, RD; Hall, RP
Published in: Dig Dis Sci
October 1999

Although possessing a morphologically similar small bowel abnormality to patients with isolated gluten-sensitive enteropathy (GSE), patients with dermatitis herpetiformis (DH) have few gastrointestinal symptoms and exhibit blistering skin lesions and cutaneous IgA deposits. To determine whether clinical discrepancies between these gluten-sensitive conditions might be the result of different patterns of small bowel cytokine expression, duodenal biopsies were obtained from eight DH patients and nine isolated GSE patients. Biopsies were evaluated for interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) expression by reverse-transcriptase polymerase chain reaction (message) and immunohistochemistry (protein). In DH patients, most of whom had no gut symptoms, IFN-gamma mRNA expression was significantly less than in isolated GSE patients with symptomatic gut disease. Conversely, IL-4 mRNA expression in DH patients was greater than that found among isolated GSE patients. These findings suggest that the different clinical phenotypes of gluten sensitivity may be caused by variation in cytokine expression in the small bowel response to gluten.

Duke Scholars

Published In

Dig Dis Sci

DOI

ISSN

0163-2116

Publication Date

October 1999

Volume

44

Issue

10

Start / End Page

2124 / 2132

Location

United States

Related Subject Headings

  • Reverse Transcriptase Polymerase Chain Reaction
  • RNA, Messenger
  • Middle Aged
  • Male
  • Interleukin-4
  • Interferon-gamma
  • Immunoenzyme Techniques
  • Humans
  • Gastroenterology & Hepatology
  • Female
 

Citation

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Smith, A. D., Bagheri, B., Streilein, R. D., & Hall, R. P. (1999). Expression of interleukin-4 and interferon-gamma in the small bowel of patients with dermatitis herpetiformis and isolated gluten-sensitive enteropathy. Dig Dis Sci, 44(10), 2124–2132. https://doi.org/10.1023/a:1026699108147
Smith, A. D., B. Bagheri, R. D. Streilein, and R. P. Hall. “Expression of interleukin-4 and interferon-gamma in the small bowel of patients with dermatitis herpetiformis and isolated gluten-sensitive enteropathy.Dig Dis Sci 44, no. 10 (October 1999): 2124–32. https://doi.org/10.1023/a:1026699108147.
Smith, A. D., et al. “Expression of interleukin-4 and interferon-gamma in the small bowel of patients with dermatitis herpetiformis and isolated gluten-sensitive enteropathy.Dig Dis Sci, vol. 44, no. 10, Oct. 1999, pp. 2124–32. Pubmed, doi:10.1023/a:1026699108147.
Journal cover image

Published In

Dig Dis Sci

DOI

ISSN

0163-2116

Publication Date

October 1999

Volume

44

Issue

10

Start / End Page

2124 / 2132

Location

United States

Related Subject Headings

  • Reverse Transcriptase Polymerase Chain Reaction
  • RNA, Messenger
  • Middle Aged
  • Male
  • Interleukin-4
  • Interferon-gamma
  • Immunoenzyme Techniques
  • Humans
  • Gastroenterology & Hepatology
  • Female