Bullous eruption of systemic lupus erythematosus. Dramatic response to dapsone therapy.

Journal Article (Journal Article)

Four patients with systemic lupus erythematosus developed a nonpruritic vesiculobullous eruption that was unresponsive to high-dose systemic corticosteroid therapy. In three patients the eruption was not associated with a flare of systemic disease. Biopsy results showed neutrophilic microabscesses at the dermal papillary tips and perivascular lymphohistiocytic infiltrates. Direct immunofluorescence of normal appearing skin not exposed to the sun was positive in all four patients. Due to the unresponsiveness to corticosteroid therapy and the striking histologic resemblance to dermatitis herpetiformis, each of the patients was treated with dapsone. Within 24 hours each patient had prompt cessation of the appearance of new lesions. Improvement of the eruption did not correlate with improvement of the systemic manifestations of their lupus erythematosus. The rapid response to dapsone therapy suggests that dapsone is useful in treating bullous lesions of systemic lupus erythematosus.

Full Text

Duke Authors

Cited Authors

  • Hall, RP; Lawley, TJ; Smith, HR; Katz, SI

Published Date

  • August 1, 1982

Published In

Volume / Issue

  • 97 / 2

Start / End Page

  • 165 - 170

PubMed ID

  • 7049027

International Standard Serial Number (ISSN)

  • 0003-4819

Digital Object Identifier (DOI)

  • 10.7326/0003-4819-97-2-165


  • eng

Conference Location

  • United States