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Reticuloendothelial system fc receptor function in rheumatoid arthritis.

Publication ,  Journal Article
Fields, TR; Gerardi, EN; Ghebrehiwet, B; Bennett, RS; Lawley, TJ; Hall, RP; Plotz, PH; Karsh, JR; Frank, MM; Hamburger, MI
Published in: J Rheumatol
August 1983

Patients with systemic lupus erythematosus (SLE) have abnormal reticuloendothelial system (RES) IgG Fc receptor function which is correlated with disease activity and levels of immune complexes (IC). We studied RES function, IC levels, clinical and laboratory manifestations in 43 patients with RA. The articular index was abnormal in 42 patients (range of 6 to 153). Thirty were seropositive; 31 had an elevated erythrocyte sedimentation rate. Extraarticular manifestations included nodules (25), anemia (19), Sjögren's syndrome (6), vasculitis (4), and Felty's syndrome (2). Medication included corticosteroids (32), nonsteroidal antiinflammatory drugs (33), slow acting antirheumatic drugs (18), and cytotoxics (2). Thirty-three patients had IC (30 by the Clq binding assay, 21 by the Raji cell assay); 13 patients had normal RES function (t 1/2-24-60 min; upper 95% confidence limit in normals = 62 min). Thirty had prolonged clearance times (65-210 min, mean 106 min). In contrast to SLE, clearance times were not found to be correlated with IC levels, or clinical or laboratory measures of disease activity. Defective RES immune clearance may not be an important determinant in the pathogenesis of immunologic tissue damage in rheumatoid arthritis.

Duke Scholars

Published In

J Rheumatol

ISSN

0315-162X

Publication Date

August 1983

Volume

10

Issue

4

Start / End Page

550 / 557

Location

Canada

Related Subject Headings

  • Rheumatoid Factor
  • Receptors, Fc
  • Mononuclear Phagocyte System
  • Middle Aged
  • Male
  • Immunoassay
  • Humans
  • Female
  • Blood Sedimentation
  • Arthritis, Rheumatoid
 

Citation

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Fields, T. R., Gerardi, E. N., Ghebrehiwet, B., Bennett, R. S., Lawley, T. J., Hall, R. P., … Hamburger, M. I. (1983). Reticuloendothelial system fc receptor function in rheumatoid arthritis. J Rheumatol, 10(4), 550–557.
Fields, T. R., E. N. Gerardi, B. Ghebrehiwet, R. S. Bennett, T. J. Lawley, R. P. Hall, P. H. Plotz, J. R. Karsh, M. M. Frank, and M. I. Hamburger. “Reticuloendothelial system fc receptor function in rheumatoid arthritis.J Rheumatol 10, no. 4 (August 1983): 550–57.
Fields TR, Gerardi EN, Ghebrehiwet B, Bennett RS, Lawley TJ, Hall RP, et al. Reticuloendothelial system fc receptor function in rheumatoid arthritis. J Rheumatol. 1983 Aug;10(4):550–7.
Fields, T. R., et al. “Reticuloendothelial system fc receptor function in rheumatoid arthritis.J Rheumatol, vol. 10, no. 4, Aug. 1983, pp. 550–57.
Fields TR, Gerardi EN, Ghebrehiwet B, Bennett RS, Lawley TJ, Hall RP, Plotz PH, Karsh JR, Frank MM, Hamburger MI. Reticuloendothelial system fc receptor function in rheumatoid arthritis. J Rheumatol. 1983 Aug;10(4):550–557.

Published In

J Rheumatol

ISSN

0315-162X

Publication Date

August 1983

Volume

10

Issue

4

Start / End Page

550 / 557

Location

Canada

Related Subject Headings

  • Rheumatoid Factor
  • Receptors, Fc
  • Mononuclear Phagocyte System
  • Middle Aged
  • Male
  • Immunoassay
  • Humans
  • Female
  • Blood Sedimentation
  • Arthritis, Rheumatoid