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Expression of cross-reactive idiotypes at the basement membrane zone in patients with bullous pemphigoid.

Publication ,  Journal Article
Rico, MJ; White, LD; Hall, RP
Published in: J Invest Dermatol
June 1993

The purpose of the present study was to determine whether tissue-bound anti-basement membrane zone (BMZ) autoantibodies in patients with bullous pemphigoid (BP) express a cross-reactive idiotype. We assayed 34 skin biopsies from 26 patients with BP and nine biopsies from control subjects, including normal subjects and patients with epidermolysis bullosa acquisita for the presence of a cross-reactive idiotype at the BMZ. Perilesional split-skin biopsies were assayed for the presence of immunoreactants, immunoglobulin G, and complement and for reactivity with a monoclonal anti-idiotypic antibody specific for a circulating anti-BMZ antibody, anti-Id 3-17. Anti-Id 3-17 bound in a linear band to the BMZ in 12 of 26 patients with BP (46%) and in 0 of 9 control subjects. In serial biopsy specimens, the presence or absence of cross-reactive idiotype at the BMZ in six patients was stable during the disease course. This cross-reactive idiotype has been previously identified in the serum of 36% of patients with BP; however, in this study, no correlation was noted between the presence of the cross-reactive idiotype in skin and serum of individual patients. Because cross-reactive idiotypes occur as a consequence of restricted variable-region gene utilization, the demonstration of a cross-reactive idiotype at the BMZ previously identified in the serum of patients with BP supports the hypothesis that circulating and tissue-bound autoantibodies in this disease arise from a common genetic origin.

Duke Scholars

Published In

J Invest Dermatol

DOI

ISSN

0022-202X

Publication Date

June 1993

Volume

100

Issue

6

Start / End Page

766 / 770

Location

United States

Related Subject Headings

  • Time Factors
  • Skin
  • Pemphigoid, Bullous
  • Humans
  • Dermatology & Venereal Diseases
  • Cross Reactions
  • Biopsy
  • Basement Membrane
  • Antibodies, Anti-Idiotypic
  • 3202 Clinical sciences
 

Citation

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Rico, M. J., White, L. D., & Hall, R. P. (1993). Expression of cross-reactive idiotypes at the basement membrane zone in patients with bullous pemphigoid. J Invest Dermatol, 100(6), 766–770. https://doi.org/10.1111/1523-1747.ep12476347
Rico, M. J., L. D. White, and R. P. Hall. “Expression of cross-reactive idiotypes at the basement membrane zone in patients with bullous pemphigoid.J Invest Dermatol 100, no. 6 (June 1993): 766–70. https://doi.org/10.1111/1523-1747.ep12476347.
Rico MJ, White LD, Hall RP. Expression of cross-reactive idiotypes at the basement membrane zone in patients with bullous pemphigoid. J Invest Dermatol. 1993 Jun;100(6):766–70.
Rico, M. J., et al. “Expression of cross-reactive idiotypes at the basement membrane zone in patients with bullous pemphigoid.J Invest Dermatol, vol. 100, no. 6, June 1993, pp. 766–70. Pubmed, doi:10.1111/1523-1747.ep12476347.
Rico MJ, White LD, Hall RP. Expression of cross-reactive idiotypes at the basement membrane zone in patients with bullous pemphigoid. J Invest Dermatol. 1993 Jun;100(6):766–770.
Journal cover image

Published In

J Invest Dermatol

DOI

ISSN

0022-202X

Publication Date

June 1993

Volume

100

Issue

6

Start / End Page

766 / 770

Location

United States

Related Subject Headings

  • Time Factors
  • Skin
  • Pemphigoid, Bullous
  • Humans
  • Dermatology & Venereal Diseases
  • Cross Reactions
  • Biopsy
  • Basement Membrane
  • Antibodies, Anti-Idiotypic
  • 3202 Clinical sciences