IgA antibodies against reticulin and endomysium in the serum and gastrointestinal secretions of patients with dermatitis herpetiformis.

Published

Journal Article

Although IgA is present in the skin of patients with dermatitis herpetiformis (DH), the relationship of that IgA to the mucosal immune response is not known. The purpose of this study was to determine if IgA antibodies directed against tissue antigens, which are present in the serum of patients with DH, are also present in the gut secretions of these patients. Serum and gut secretions from 8 patients with DH and 5 control subjects were analyzed by indirect immunofluorescence for the presence of IgA antireticulin and antiendomysium antibodies. IgA antibodies against reticulin (3 of 8 patients) and endomysium (4 of 8 patients) were found in the serum of patients with DH. IgA antibodies were also present in the gut secretions of all of these patients, but not in subjects (patients with DH and controls) that did not have serum IgA antireticulin or antiendomysium antibodies. The presence of IgA antireticulin and antiendomysium in both the serum and gut secretions of DH patients suggests that these antibodies arise as a result of the mucosal immune response and that IgA of mucosal origin can persist in the serum of patients with DH.

Full Text

Duke Authors

Cited Authors

  • McCord, ML; Hall, RP

Published Date

  • 1994

Published In

Volume / Issue

  • 189 Suppl 1 /

Start / End Page

  • 60 - 63

PubMed ID

  • 8049567

Pubmed Central ID

  • 8049567

International Standard Serial Number (ISSN)

  • 1018-8665

Digital Object Identifier (DOI)

  • 10.1159/000246932

Language

  • eng

Conference Location

  • Switzerland