Combination treatment of bullous pemphigoid with anti-CD20 and anti-CD25 antibodies in a patient with chronic graft-versus-host disease.

Published

Journal Article

In this case report we describe a novel treatment with two chimeric monoclonal antibodies (MoAb) targeting the autoimmune B cell clone responsible for bullous pemphigoid (BP) as a manifestation of steroid refractory chronic graft-versus-host disease (GVHD) that developed after unrelated cord blood transplantation. Monitoring the BP-specific circulating antibodies and CD25-expressing activated T lymphocyte subset led us to combine anti-CD20 (Rituximab) mediated B cell ablation with anti-CD25 (Daclizumab) therapy to block CD4(+) T cell help. Complete clinical and serologic response was achieved within 4 weeks of initiation of therapy allowing global immunosuppression to be dramatically reduced.

Full Text

Duke Authors

Cited Authors

  • Szabolcs, P; Reese, M; Yancey, KB; Hall, RP; Kurtzberg, J

Published Date

  • September 2002

Published In

Volume / Issue

  • 30 / 5

Start / End Page

  • 327 - 329

PubMed ID

  • 12209356

Pubmed Central ID

  • 12209356

International Standard Serial Number (ISSN)

  • 0268-3369

Digital Object Identifier (DOI)

  • 10.1038/sj.bmt.1703654

Language

  • eng

Conference Location

  • England