Anti-idiotypic antibodies as vaccine candidates. The immune network.
Publication
, Journal Article
Rico, MJ; Hall, RP
Published in: Arch Dermatol
February 1989
Antibodies specific for determinants within the variable region of an antibody molecule are known as anti-idiotypic antibodies. Anti-idiotypic antibodies specific for determinants within the antigen binding site of the antibody may mimic the original antigen and are said to bear an "internal image" of the antigen. These anti-idiotypic antibodies have been shown in animal studies to function as surrogate antigens in stimulating an immune response and may ultimately be useful therapeutically as vaccines to prevent infectious diseases, to enhance the immune response to neoplasms, and to modulate autoantibody production in autoimmune diseases.
Duke Scholars
Published In
Arch Dermatol
ISSN
0003-987X
Publication Date
February 1989
Volume
125
Issue
2
Start / End Page
271 / 275
Location
United States
Related Subject Headings
- Viral Envelope Proteins
- Vaccines
- T-Lymphocytes
- Neoplasms
- Mice
- Immunoglobulin Idiotypes
- Humans
- HIV
- Dermatology & Venereal Diseases
- Autoimmune Diseases
Citation
APA
Chicago
ICMJE
MLA
NLM
Rico, M. J., & Hall, R. P. (1989). Anti-idiotypic antibodies as vaccine candidates. The immune network. Arch Dermatol, 125(2), 271–275.
Rico, M. J., and R. P. Hall. “Anti-idiotypic antibodies as vaccine candidates. The immune network.” Arch Dermatol 125, no. 2 (February 1989): 271–75.
Rico MJ, Hall RP. Anti-idiotypic antibodies as vaccine candidates. The immune network. Arch Dermatol. 1989 Feb;125(2):271–5.
Rico, M. J., and R. P. Hall. “Anti-idiotypic antibodies as vaccine candidates. The immune network.” Arch Dermatol, vol. 125, no. 2, Feb. 1989, pp. 271–75.
Rico MJ, Hall RP. Anti-idiotypic antibodies as vaccine candidates. The immune network. Arch Dermatol. 1989 Feb;125(2):271–275.
Published In
Arch Dermatol
ISSN
0003-987X
Publication Date
February 1989
Volume
125
Issue
2
Start / End Page
271 / 275
Location
United States
Related Subject Headings
- Viral Envelope Proteins
- Vaccines
- T-Lymphocytes
- Neoplasms
- Mice
- Immunoglobulin Idiotypes
- Humans
- HIV
- Dermatology & Venereal Diseases
- Autoimmune Diseases