Cross-reactive idiotypes in the sera of patients with bullous pemphigoid express anti-basement-membrane-zone activity.
Journal Article (Journal Article)
We have previously generated a monoclonal anti-idiotypic antibody (antiId 3-17) specific for a cross-reactive idiotype (CRI) present in sera and bound at the basement membrane zone (BMZ) in some patients with bullous pemphigoid (BP). The purpose of the present study was to determine if CRI isolated from sera of patients with BP expressed anti-BMZ activity. CRI, isolated by affinity chromatography from 5 nonrelated patients with BP, bound to the epidermal side of normal human split skin as detected by indirect immunofluorescence. In patients with BP, the presence of the CRI on circulating IgG is associated with anti-BMZ activity.
Full Text
Duke Authors
Cited Authors
- Rico, MJ; Hall, RP
Published Date
- 1994
Published In
Volume / Issue
- 189 Suppl 1 /
Start / End Page
- 72 - 75
PubMed ID
- 7519488
Pubmed Central ID
- 7519488
International Standard Serial Number (ISSN)
- 1018-8665
Digital Object Identifier (DOI)
- 10.1159/000246935
Language
- eng
Conference Location
- Switzerland