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Cross-reactive idiotypes in the sera of patients with bullous pemphigoid express anti-basement-membrane-zone activity.

Publication ,  Journal Article
Rico, MJ; Hall, RP
Published in: Dermatology
1994

We have previously generated a monoclonal anti-idiotypic antibody (antiId 3-17) specific for a cross-reactive idiotype (CRI) present in sera and bound at the basement membrane zone (BMZ) in some patients with bullous pemphigoid (BP). The purpose of the present study was to determine if CRI isolated from sera of patients with BP expressed anti-BMZ activity. CRI, isolated by affinity chromatography from 5 nonrelated patients with BP, bound to the epidermal side of normal human split skin as detected by indirect immunofluorescence. In patients with BP, the presence of the CRI on circulating IgG is associated with anti-BMZ activity.

Duke Scholars

Published In

Dermatology

DOI

ISSN

1018-8665

Publication Date

1994

Volume

189 Suppl 1

Start / End Page

72 / 75

Location

Switzerland

Related Subject Headings

  • Skin
  • Pemphigoid, Bullous
  • Immunoglobulin G
  • Humans
  • Epitopes
  • Dermatology & Venereal Diseases
  • Cross Reactions
  • Chromatography, Affinity
  • Basement Membrane
  • Autoantibodies
 

Citation

APA
Chicago
ICMJE
MLA
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Rico, M. J., & Hall, R. P. (1994). Cross-reactive idiotypes in the sera of patients with bullous pemphigoid express anti-basement-membrane-zone activity. Dermatology, 189 Suppl 1, 72–75. https://doi.org/10.1159/000246935
Rico, M. J., and R. P. Hall. “Cross-reactive idiotypes in the sera of patients with bullous pemphigoid express anti-basement-membrane-zone activity.Dermatology 189 Suppl 1 (1994): 72–75. https://doi.org/10.1159/000246935.
Rico, M. J., and R. P. Hall. “Cross-reactive idiotypes in the sera of patients with bullous pemphigoid express anti-basement-membrane-zone activity.Dermatology, vol. 189 Suppl 1, 1994, pp. 72–75. Pubmed, doi:10.1159/000246935.
Journal cover image

Published In

Dermatology

DOI

ISSN

1018-8665

Publication Date

1994

Volume

189 Suppl 1

Start / End Page

72 / 75

Location

Switzerland

Related Subject Headings

  • Skin
  • Pemphigoid, Bullous
  • Immunoglobulin G
  • Humans
  • Epitopes
  • Dermatology & Venereal Diseases
  • Cross Reactions
  • Chromatography, Affinity
  • Basement Membrane
  • Autoantibodies