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The use of a transscrotal testosterone delivery system in the treatment of patients with weight loss related to human immunodeficiency virus infection.

Publication ,  Journal Article
Dobs, AS; Cofrancesco, J; Nolten, WE; Danoff, A; Anderson, R; Hamilton, CD; Feinberg, J; Seekins, D; Yangco, B; Rhame, F
Published in: Am J Med
August 1999

PURPOSE: Weight loss is a strong predictor of morbidity and mortality in human immunodeficiency virus (HIV)-infected patients. Men with acquired immunodeficiency syndrome (AIDS) lose body cell mass. Hypogonadism is also common. This study tested the efficacy of a testosterone transscrotal patch (6 mg/day) in improving body cell mass and treating hypogonadism in these patients. SUBJECTS AND METHODS: This multicenter, randomized, double-blinded, placebo-controlled trial was conducted from August 1995 to October 1996 in 133 men, 18 years of age and older, who had AIDS, 5% to 20% weight loss, and either a low morning serum total testosterone level (<400 ng/dL) or a low free testosterone level (<16 pg/mL). Outcomes included weight, body cell mass as measured using bioelectrical impedance analysis, quality of life, and morning measurements of serum testosterone and dihydrotestosterone levels, lymphocyte subsets, and HIV quantification. RESULTS: There were no significant differences in baseline weight, CD4 cell counts, or HIV serum viral quantification between treatment arms. Morning total and free testosterone levels increased in those treated with testosterone, but not with placebo. Following 12 weeks of treatment there were no differences (testosterone-placebo) in mean weight change (-0.3 kg [95% confidence interval (CI): -1.4 to 0.8]) or body cell mass (-0.2 kg [95% CI: -1.0 to 0.6]) in the two groups. There were also no changes in quality of life in either group. CONCLUSION: Hypogonadal men with AIDS and weight loss can achieve adequate morning serum sex hormone levels using a transscrotal testosterone patch. However, this system of replacement does not improve weight, body cell mass, or quality of life.

Duke Scholars

Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

August 1999

Volume

107

Issue

2

Start / End Page

126 / 132

Location

United States

Related Subject Headings

  • Weight Loss
  • Testosterone
  • Scrotum
  • Middle Aged
  • Male
  • Humans
  • HIV Infections
  • General & Internal Medicine
  • Double-Blind Method
  • Aged
 

Citation

APA
Chicago
ICMJE
MLA
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Dobs, A. S., Cofrancesco, J., Nolten, W. E., Danoff, A., Anderson, R., Hamilton, C. D., … Rhame, F. (1999). The use of a transscrotal testosterone delivery system in the treatment of patients with weight loss related to human immunodeficiency virus infection. Am J Med, 107(2), 126–132. https://doi.org/10.1016/s0002-9343(99)00193-x
Dobs, A. S., J. Cofrancesco, W. E. Nolten, A. Danoff, R. Anderson, C. D. Hamilton, J. Feinberg, D. Seekins, B. Yangco, and F. Rhame. “The use of a transscrotal testosterone delivery system in the treatment of patients with weight loss related to human immunodeficiency virus infection.Am J Med 107, no. 2 (August 1999): 126–32. https://doi.org/10.1016/s0002-9343(99)00193-x.
Dobs AS, Cofrancesco J, Nolten WE, Danoff A, Anderson R, Hamilton CD, et al. The use of a transscrotal testosterone delivery system in the treatment of patients with weight loss related to human immunodeficiency virus infection. Am J Med. 1999 Aug;107(2):126–32.
Dobs, A. S., et al. “The use of a transscrotal testosterone delivery system in the treatment of patients with weight loss related to human immunodeficiency virus infection.Am J Med, vol. 107, no. 2, Aug. 1999, pp. 126–32. Pubmed, doi:10.1016/s0002-9343(99)00193-x.
Dobs AS, Cofrancesco J, Nolten WE, Danoff A, Anderson R, Hamilton CD, Feinberg J, Seekins D, Yangco B, Rhame F. The use of a transscrotal testosterone delivery system in the treatment of patients with weight loss related to human immunodeficiency virus infection. Am J Med. 1999 Aug;107(2):126–132.
Journal cover image

Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

August 1999

Volume

107

Issue

2

Start / End Page

126 / 132

Location

United States

Related Subject Headings

  • Weight Loss
  • Testosterone
  • Scrotum
  • Middle Aged
  • Male
  • Humans
  • HIV Infections
  • General & Internal Medicine
  • Double-Blind Method
  • Aged