The prevalence of abnormal cilia in normal pediatric lungs.

Journal Article (Journal Article)

Abnormal respiratory cells have been reported in cases of chronic pediatric respiratory infection. In some cases, there is a specific defect of most cilia, but in others there is a variety of derangements of the architecture of only a fraction of the cilia. Histologically normal lungs from two children without known respiratory disease were examined and found to contain many abnormal cilia of the polymorphic type, which accounted for 3% to 5% of all cilia. Abnormalities included (1) excess cytoplasmic matrix, (2) additions, deletions, or aberrant arrangements of the 9 + 2 tubular pattern, (3) multiple partial or complete cilia within one membrane, and (4) occasional marked disorganization of all cilia in a cell. Polymorphic ciliary abnormalities may be common in healthy children, and should be cautiously interpreted as a cause of chronic respiratory infection.

Full Text

Duke Authors

Cited Authors

  • Wisseman, CL; Simel, DL; Spock, A; Shelburne, JD

Published Date

  • October 1, 1981

Published In

Volume / Issue

  • 105 / 10

Start / End Page

  • 552 - 555

PubMed ID

  • 6895171

International Standard Serial Number (ISSN)

  • 0003-9985


  • eng

Conference Location

  • United States