Identification of susceptibility loci contributing to a complex disease using conventional segregation, linkage, and association methods.
Journal Article (Journal Article)
We set out to apply conventional analytic methods to a GAW data set of nuclear families with an oligogenic disease that has a population prevalence of 0.023. We chose methods generally applied to disorders with at least one major gene. Our approaches included: 1) complex segregation analysis under two models of ascertainment, 2) linkage analysis assuming either a single-locus trait with possible genetic heterogeneity or a two-locus trait, and 3) allelic association studies using both a case/control approach and the haplotype relative risk (HRR) test. The association study was the only analysis of the three that provided evidence for genes playing a role in the etiology of this disorder.
Full Text
Duke Authors
Cited Authors
- Falk, CT; Ashley, A; Lamb, N; Sherman, SL
Published Date
- 1995
Published In
Volume / Issue
- 12 / 6
Start / End Page
- 601 - 606
PubMed ID
- 8787980
Pubmed Central ID
- 8787980
International Standard Serial Number (ISSN)
- 0741-0395
Digital Object Identifier (DOI)
- 10.1002/gepi.1370120613
Language
- eng
Conference Location
- United States