Identification of susceptibility loci contributing to a complex disease using conventional segregation, linkage, and association methods.
Publication
, Journal Article
Falk, CT; Ashley, A; Lamb, N; Sherman, SL
Published in: Genet Epidemiol
1995
We set out to apply conventional analytic methods to a GAW data set of nuclear families with an oligogenic disease that has a population prevalence of 0.023. We chose methods generally applied to disorders with at least one major gene. Our approaches included: 1) complex segregation analysis under two models of ascertainment, 2) linkage analysis assuming either a single-locus trait with possible genetic heterogeneity or a two-locus trait, and 3) allelic association studies using both a case/control approach and the haplotype relative risk (HRR) test. The association study was the only analysis of the three that provided evidence for genes playing a role in the etiology of this disorder.
Duke Scholars
Published In
Genet Epidemiol
DOI
ISSN
0741-0395
Publication Date
1995
Volume
12
Issue
6
Start / End Page
601 / 606
Location
United States
Related Subject Headings
- Risk Assessment
- Prevalence
- Models, Genetic
- Male
- Lod Score
- Humans
- Haplotypes
- Genetics, Population
- Genetic Predisposition to Disease
- Genetic Diseases, Inborn
Citation
APA
Chicago
ICMJE
MLA
NLM
Falk, C. T., Ashley, A., Lamb, N., & Sherman, S. L. (1995). Identification of susceptibility loci contributing to a complex disease using conventional segregation, linkage, and association methods. Genet Epidemiol, 12(6), 601–606. https://doi.org/10.1002/gepi.1370120613
Falk, C. T., A. Ashley, N. Lamb, and S. L. Sherman. “Identification of susceptibility loci contributing to a complex disease using conventional segregation, linkage, and association methods.” Genet Epidemiol 12, no. 6 (1995): 601–6. https://doi.org/10.1002/gepi.1370120613.
Falk CT, Ashley A, Lamb N, Sherman SL. Identification of susceptibility loci contributing to a complex disease using conventional segregation, linkage, and association methods. Genet Epidemiol. 1995;12(6):601–6.
Falk, C. T., et al. “Identification of susceptibility loci contributing to a complex disease using conventional segregation, linkage, and association methods.” Genet Epidemiol, vol. 12, no. 6, 1995, pp. 601–06. Pubmed, doi:10.1002/gepi.1370120613.
Falk CT, Ashley A, Lamb N, Sherman SL. Identification of susceptibility loci contributing to a complex disease using conventional segregation, linkage, and association methods. Genet Epidemiol. 1995;12(6):601–606.
Published In
Genet Epidemiol
DOI
ISSN
0741-0395
Publication Date
1995
Volume
12
Issue
6
Start / End Page
601 / 606
Location
United States
Related Subject Headings
- Risk Assessment
- Prevalence
- Models, Genetic
- Male
- Lod Score
- Humans
- Haplotypes
- Genetics, Population
- Genetic Predisposition to Disease
- Genetic Diseases, Inborn