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Identification of susceptibility loci contributing to a complex disease using conventional segregation, linkage, and association methods.

Publication ,  Journal Article
Falk, CT; Ashley, A; Lamb, N; Sherman, SL
Published in: Genet Epidemiol
1995

We set out to apply conventional analytic methods to a GAW data set of nuclear families with an oligogenic disease that has a population prevalence of 0.023. We chose methods generally applied to disorders with at least one major gene. Our approaches included: 1) complex segregation analysis under two models of ascertainment, 2) linkage analysis assuming either a single-locus trait with possible genetic heterogeneity or a two-locus trait, and 3) allelic association studies using both a case/control approach and the haplotype relative risk (HRR) test. The association study was the only analysis of the three that provided evidence for genes playing a role in the etiology of this disorder.

Duke Scholars

Published In

Genet Epidemiol

DOI

ISSN

0741-0395

Publication Date

1995

Volume

12

Issue

6

Start / End Page

601 / 606

Location

United States

Related Subject Headings

  • Risk Assessment
  • Prevalence
  • Models, Genetic
  • Male
  • Lod Score
  • Humans
  • Haplotypes
  • Genetics, Population
  • Genetic Predisposition to Disease
  • Genetic Diseases, Inborn
 

Citation

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Falk, C. T., Ashley, A., Lamb, N., & Sherman, S. L. (1995). Identification of susceptibility loci contributing to a complex disease using conventional segregation, linkage, and association methods. Genet Epidemiol, 12(6), 601–606. https://doi.org/10.1002/gepi.1370120613
Falk, C. T., A. Ashley, N. Lamb, and S. L. Sherman. “Identification of susceptibility loci contributing to a complex disease using conventional segregation, linkage, and association methods.Genet Epidemiol 12, no. 6 (1995): 601–6. https://doi.org/10.1002/gepi.1370120613.
Falk, C. T., et al. “Identification of susceptibility loci contributing to a complex disease using conventional segregation, linkage, and association methods.Genet Epidemiol, vol. 12, no. 6, 1995, pp. 601–06. Pubmed, doi:10.1002/gepi.1370120613.
Journal cover image

Published In

Genet Epidemiol

DOI

ISSN

0741-0395

Publication Date

1995

Volume

12

Issue

6

Start / End Page

601 / 606

Location

United States

Related Subject Headings

  • Risk Assessment
  • Prevalence
  • Models, Genetic
  • Male
  • Lod Score
  • Humans
  • Haplotypes
  • Genetics, Population
  • Genetic Predisposition to Disease
  • Genetic Diseases, Inborn