Genomic screen and follow-up analysis for autistic disorder.

Journal Article (Journal Article)

Autistic disorder (AutD) is a neurodevelopmental disorder characterized by significant impairment in social, communicative, and behavioral functioning. A genetic basis for AutD is well established with as many as 10 genes postulated to contribute to its underlying etiology. We have completed a genomic screen and follow-up analysis to identify potential AutD susceptibility loci. In stage one of the genome screen, 52 multiplex families (two or more AutD affected individuals/family) were genotyped with 352 genetic markers to yield an approximately 10 centimorgan (cM) grid, inclusive of the X chromosome. The selection criterion for follow-up of interesting regions was a maximum heterogeneity lod score (MLOD) or a maximum nonparametric sib pair lod score (MLS) of at least 1.0. Eight promising regions were identified on chromosomes 2, 3, 7, 15, 18, 19, and X. In the stage two follow-up study we analyzed an additional 47 multiplex families (total=99 families). Regions on chromosomes 2, 3, 7, 15, 19, and X remained interesting (MLOD> or =1.0) in stage two analysis. The peak lod score regions on chromosomes 2, 7, 15, 19, and X overlap previously reported peak linkage areas. The region on chromosome 3 is unique.

Full Text

Duke Authors

Cited Authors

  • Shao, Y; Wolpert, CM; Raiford, KL; Menold, MM; Donnelly, SL; Ravan, SA; Bass, MP; McClain, C; von Wendt, L; Vance, JM; Abramson, RH; Wright, HH; Ashley-Koch, A; Gilbert, JR; DeLong, RG; Cuccaro, ML; Pericak-Vance, MA

Published Date

  • January 8, 2002

Published In

Volume / Issue

  • 114 / 1

Start / End Page

  • 99 - 105

PubMed ID

  • 11840513

International Standard Serial Number (ISSN)

  • 0148-7299

Digital Object Identifier (DOI)

  • 10.1002/ajmg.10153


  • eng

Conference Location

  • United States