Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis.


Journal Article

Dopamine supersensitivity occurs in schizophrenia and other psychoses, and after hippocampal lesions, antipsychotics, ethanol, amphetamine, phencyclidine, gene knockouts of Dbh (dopamine beta-hydroxylase), Drd4 receptors, Gprk6 (G protein-coupled receptor kinase 6), Comt (catechol-O-methyltransferase), or Th-/-, DbhTh/+ (tyrosine hydroxylase), and in rats born by Cesarean-section. The functional state of D2, or the high-affinity state for dopamine (D2High), was measured in these supersensitive animal brain striata. Increased levels and higher proportions (40-900%) for D2High were found in all these tissues. If many types of brain impairment cause dopamine behavioral supersensitivity and a common increase in D2High states, it suggests that there are many pathways to psychosis, any one of which can be disrupted.

Full Text

Cited Authors

  • Seeman, P; Weinshenker, D; Quirion, R; Srivastava, LK; Bhardwaj, SK; Grandy, DK; Premont, RT; Sotnikova, TD; Boksa, P; El-Ghundi, M; O'dowd, BF; George, SR; Perreault, ML; Männistö, PT; Robinson, S; Palmiter, RD; Tallerico, T

Published Date

  • March 2005

Published In

Volume / Issue

  • 102 / 9

Start / End Page

  • 3513 - 3518

PubMed ID

  • 15716360

Pubmed Central ID

  • 15716360

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.0409766102


  • eng