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Induction of protective CTL responses in newborn mice by a murine retrovirus.

Publication ,  Journal Article
Sarzotti, M; Robbins, DS; Hoffman, PM
Published in: Science
March 22, 1996

The susceptibility of neonates to virus-induced disease is thought to reflect, in part, the immaturity of their immune systems. However, inoculation of newborn mice with low doses of Cas-Br-M murine leukemia virus induced a protective cytotoxic T lymphocyte (CTL) response. The inability of neonates to develop a CTL response to high doses of virus was not the result of immunological immaturity but correlated with the induction of a nonprotective type 2 cytokine response. Thus, the initial viral dose is critical in the development of protective immunity in newborns.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

March 22, 1996

Volume

271

Issue

5256

Start / End Page

1726 / 1728

Location

United States

Related Subject Headings

  • Tumor Virus Infections
  • T-Lymphocytes, Cytotoxic
  • Retroviridae Infections
  • Mice
  • Leukemia Virus, Murine
  • Interleukin-4
  • Interferon-gamma
  • Immunotherapy, Adoptive
  • General Science & Technology
  • Dose-Response Relationship, Immunologic
 

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Sarzotti, M., Robbins, D. S., & Hoffman, P. M. (1996). Induction of protective CTL responses in newborn mice by a murine retrovirus. Science, 271(5256), 1726–1728. https://doi.org/10.1126/science.271.5256.1726
Sarzotti, M., D. S. Robbins, and P. M. Hoffman. “Induction of protective CTL responses in newborn mice by a murine retrovirus.Science 271, no. 5256 (March 22, 1996): 1726–28. https://doi.org/10.1126/science.271.5256.1726.
Sarzotti M, Robbins DS, Hoffman PM. Induction of protective CTL responses in newborn mice by a murine retrovirus. Science. 1996 Mar 22;271(5256):1726–8.
Sarzotti, M., et al. “Induction of protective CTL responses in newborn mice by a murine retrovirus.Science, vol. 271, no. 5256, Mar. 1996, pp. 1726–28. Pubmed, doi:10.1126/science.271.5256.1726.
Sarzotti M, Robbins DS, Hoffman PM. Induction of protective CTL responses in newborn mice by a murine retrovirus. Science. 1996 Mar 22;271(5256):1726–1728.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

March 22, 1996

Volume

271

Issue

5256

Start / End Page

1726 / 1728

Location

United States

Related Subject Headings

  • Tumor Virus Infections
  • T-Lymphocytes, Cytotoxic
  • Retroviridae Infections
  • Mice
  • Leukemia Virus, Murine
  • Interleukin-4
  • Interferon-gamma
  • Immunotherapy, Adoptive
  • General Science & Technology
  • Dose-Response Relationship, Immunologic