Induction of protective CTL responses in newborn mice by a murine retrovirus.
Publication
, Journal Article
Sarzotti, M; Robbins, DS; Hoffman, PM
Published in: Science
March 22, 1996
The susceptibility of neonates to virus-induced disease is thought to reflect, in part, the immaturity of their immune systems. However, inoculation of newborn mice with low doses of Cas-Br-M murine leukemia virus induced a protective cytotoxic T lymphocyte (CTL) response. The inability of neonates to develop a CTL response to high doses of virus was not the result of immunological immaturity but correlated with the induction of a nonprotective type 2 cytokine response. Thus, the initial viral dose is critical in the development of protective immunity in newborns.
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Published In
Science
DOI
ISSN
0036-8075
Publication Date
March 22, 1996
Volume
271
Issue
5256
Start / End Page
1726 / 1728
Location
United States
Related Subject Headings
- Tumor Virus Infections
- T-Lymphocytes, Cytotoxic
- Retroviridae Infections
- Mice
- Leukemia Virus, Murine
- Interleukin-4
- Interferon-gamma
- Immunotherapy, Adoptive
- General Science & Technology
- Dose-Response Relationship, Immunologic
Citation
APA
Chicago
ICMJE
MLA
NLM
Sarzotti, M., Robbins, D. S., & Hoffman, P. M. (1996). Induction of protective CTL responses in newborn mice by a murine retrovirus. Science, 271(5256), 1726–1728. https://doi.org/10.1126/science.271.5256.1726
Sarzotti, M., D. S. Robbins, and P. M. Hoffman. “Induction of protective CTL responses in newborn mice by a murine retrovirus.” Science 271, no. 5256 (March 22, 1996): 1726–28. https://doi.org/10.1126/science.271.5256.1726.
Sarzotti M, Robbins DS, Hoffman PM. Induction of protective CTL responses in newborn mice by a murine retrovirus. Science. 1996 Mar 22;271(5256):1726–8.
Sarzotti, M., et al. “Induction of protective CTL responses in newborn mice by a murine retrovirus.” Science, vol. 271, no. 5256, Mar. 1996, pp. 1726–28. Pubmed, doi:10.1126/science.271.5256.1726.
Sarzotti M, Robbins DS, Hoffman PM. Induction of protective CTL responses in newborn mice by a murine retrovirus. Science. 1996 Mar 22;271(5256):1726–1728.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
March 22, 1996
Volume
271
Issue
5256
Start / End Page
1726 / 1728
Location
United States
Related Subject Headings
- Tumor Virus Infections
- T-Lymphocytes, Cytotoxic
- Retroviridae Infections
- Mice
- Leukemia Virus, Murine
- Interleukin-4
- Interferon-gamma
- Immunotherapy, Adoptive
- General Science & Technology
- Dose-Response Relationship, Immunologic