Induction of protective CTL responses in newborn mice by a murine retrovirus.

Journal Article (Journal Article)

The susceptibility of neonates to virus-induced disease is thought to reflect, in part, the immaturity of their immune systems. However, inoculation of newborn mice with low doses of Cas-Br-M murine leukemia virus induced a protective cytotoxic T lymphocyte (CTL) response. The inability of neonates to develop a CTL response to high doses of virus was not the result of immunological immaturity but correlated with the induction of a nonprotective type 2 cytokine response. Thus, the initial viral dose is critical in the development of protective immunity in newborns.

Full Text

Duke Authors

Cited Authors

  • Sarzotti, M; Robbins, DS; Hoffman, PM

Published Date

  • March 22, 1996

Published In

Volume / Issue

  • 271 / 5256

Start / End Page

  • 1726 - 1728

PubMed ID

  • 8596933

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.271.5256.1726

Language

  • eng

Conference Location

  • United States