Induction of protective CTL responses in newborn mice by a murine retrovirus.
Journal Article (Journal Article)
The susceptibility of neonates to virus-induced disease is thought to reflect, in part, the immaturity of their immune systems. However, inoculation of newborn mice with low doses of Cas-Br-M murine leukemia virus induced a protective cytotoxic T lymphocyte (CTL) response. The inability of neonates to develop a CTL response to high doses of virus was not the result of immunological immaturity but correlated with the induction of a nonprotective type 2 cytokine response. Thus, the initial viral dose is critical in the development of protective immunity in newborns.
Full Text
Duke Authors
Cited Authors
- Sarzotti, M; Robbins, DS; Hoffman, PM
Published Date
- March 22, 1996
Published In
Volume / Issue
- 271 / 5256
Start / End Page
- 1726 - 1728
PubMed ID
- 8596933
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.271.5256.1726
Language
- eng
Conference Location
- United States