Postinfection therapy of arbovirus infections in mice.

Published

Journal Article

Most antiviral agents are efficacious prophylactically in vivo, and a few are efficacious for postinfection (p.i.) therapy. To explore possibilities for p.i. therapy of encephalogenic Banzi virus (BZV) and Semliki Forest virus infections in mice, we evaluated candidate antiviral therapies after development of the first clinical signs of infection. The earliest clinical indication of BZV viremia in mice is a rise in core body temperature beginning on day 3 p.i. BZV-infected mice showing elevated core body temperatures (greater than or equal to 37.3 degrees C) on days 3 and 4 p.i. were treated intraperitoneally with the interferon inducer poly(ICLC) (80 micrograms per mouse) and/or specific antiserum. Combined therapy on day 3 of a BZV infection protected over 75% of mice showing clinical evidence of viral disease before treatment. Protection against early brain infection must occur on day 4 p.i., since by that day BZV has started multiplying in the brains of the mice. Significant protection occurred with antiserum alone and increased with poly(ICLC). Similar protection was obtained during Semliki Forest virus viremia, but this infection is so rapid that the first clinical signs are reliably detectable only after viremia.

Full Text

Duke Authors

Cited Authors

  • Singh, IP; Coppenhaver, DH; Sarzotti, M; Sriyuktasuth, P; Poast, J; Levy, HB; Baron, S

Published Date

  • December 1989

Published In

Volume / Issue

  • 33 / 12

Start / End Page

  • 2126 - 2131

PubMed ID

  • 2619276

Pubmed Central ID

  • 2619276

International Standard Serial Number (ISSN)

  • 0066-4804

Digital Object Identifier (DOI)

  • 10.1128/aac.33.12.2126

Language

  • eng

Conference Location

  • United States