IFN-gamma production in response to neuropathogenic Cas-Br-M murine leukemia virus infection.
Journal Article (Journal Article)
T cell-mediated production of IFN-gamma followed infection of adult, but not neonatal NFS/N mice with Cas-Br-M murine leukemia virus (Cas). The IFN-gamma response was associated with the appearance of CTL specific for Cas and with age-dependent resistance to neurologic disease. While both immune responses were mediated by a CD8-enriched population of T cells, IFN-gamma did not play a role in the activation of the Cas-specific CTL response. However, when given exogenously, IFN-gamma delayed the onset and reduced the incidence of Cas-induced neurologic disease. These data suggest that the IFN-gamma response to Cas infection may be an important host defense mechanism whose effects on virus replication and neurologic disease expression are independent of its effect on Cas-specific CTL.
Full Text
Duke Authors
Cited Authors
- Sarzotti, M; Gomes, MDP; Hoffman, PM
Published Date
- 1993
Published In
Volume / Issue
- 6 / 3
Start / End Page
- 207 - 217
PubMed ID
- 8292227
International Standard Serial Number (ISSN)
- 0882-8245
Digital Object Identifier (DOI)
- 10.1089/vim.1993.6.207
Language
- eng
Conference Location
- United States