IFN-gamma production in response to neuropathogenic Cas-Br-M murine leukemia virus infection.

Journal Article

T cell-mediated production of IFN-gamma followed infection of adult, but not neonatal NFS/N mice with Cas-Br-M murine leukemia virus (Cas). The IFN-gamma response was associated with the appearance of CTL specific for Cas and with age-dependent resistance to neurologic disease. While both immune responses were mediated by a CD8-enriched population of T cells, IFN-gamma did not play a role in the activation of the Cas-specific CTL response. However, when given exogenously, IFN-gamma delayed the onset and reduced the incidence of Cas-induced neurologic disease. These data suggest that the IFN-gamma response to Cas infection may be an important host defense mechanism whose effects on virus replication and neurologic disease expression are independent of its effect on Cas-specific CTL.

Full Text

Duke Authors

Cited Authors

  • Sarzotti, M; Gomes, MDP; Hoffman, PM

Published Date

  • 1993

Published In

Volume / Issue

  • 6 / 3

Start / End Page

  • 207 - 217

PubMed ID

  • 8292227

International Standard Serial Number (ISSN)

  • 0882-8245

Digital Object Identifier (DOI)

  • 10.1089/vim.1993.6.207

Language

  • eng

Conference Location

  • United States