Perceiving patterns in random series: dynamic processing of sequence in prefrontal cortex.

Journal Article (Clinical Trial;Journal Article)

We demonstrate that regions within human prefrontal cortex develop moment-to-moment models for patterns of events occurring in the sensory environment. Subjects viewed a random binary sequence of images, each presented singly and each requiring a different button press response. Patterns occurred by chance within the presented series of images. Using functional magnetic resonance imaging (fMRI), we identified activity evoked by viewing a stimulus that interrupted a pattern. Prefrontal activation was evoked by violations of both repeating and alternating patterns, and the amplitude of this activation increased with increasing pattern length. Violations of repeating patterns, but not of alternating patterns, activated the basal ganglia.

Full Text

Duke Authors

Cited Authors

  • Huettel, SA; Mack, PB; McCarthy, G

Published Date

  • May 2002

Published In

Volume / Issue

  • 5 / 5

Start / End Page

  • 485 - 490

PubMed ID

  • 11941373

Electronic International Standard Serial Number (EISSN)

  • 1546-1726

International Standard Serial Number (ISSN)

  • 1097-6256

Digital Object Identifier (DOI)

  • 10.1038/nn841


  • eng