Modulation of prefrontal cortex activity by information toward a decision rule.


Journal Article

We used fMRI to investigate how the information content of a stimulus influences activity in brain systems that support decision making. Subjects learned decision rules that were based upon the color, shape, or fill pattern of a series of stimuli. Each stimulus was classified by its information content, defined formally by the decision rules it excluded. While activity in dorsolateral prefrontal cortex (dlPFC) increased with increasing stimulus information, activity in the striatum did not. In contrast, within both the striatum and dlPFC, stimuli consistent with the rule evoked greater activity than stimuli inconsistent with the rule. This dissociation indicates that dlPFC supports modification of sets of stimulus-response contingencies while the striatum supports stimulus-specific learning.

Full Text

Duke Authors

Cited Authors

  • Huettel, SA; Misiurek, J

Published Date

  • August 2004

Published In

Volume / Issue

  • 15 / 12

Start / End Page

  • 1883 - 1886

PubMed ID

  • 15305129

Pubmed Central ID

  • 15305129

Electronic International Standard Serial Number (EISSN)

  • 1473-558X

International Standard Serial Number (ISSN)

  • 0959-4965

Digital Object Identifier (DOI)

  • 10.1097/00001756-200408260-00009


  • eng