Menstrual cycle effects on caffeine elimination in the human female.

Journal Article (Journal Article)

Increases in the levels of sex steroids due to pregnancy or oral contraceptive steroid use are known to decrease significantly the rate at which caffeine is eliminated from the body. An investigation has now been made into whether the changes in sex steroid levels that occur during normal menstrual cycling also affect the rate of caffeine elimination, especially whether hormonal shifts in the luteal phase are associated with slower elimination of caffeine. Repeated 24-hour caffeine elimination studies were conducted during the follicular and luteal phases of the menstrual cycle in 10 healthy women. Comparisons of the follicular and luteal phases revealed that systemic clearance of caffeine was slower in the luteal phase, although the t1/2 did not differ. The slowing effect was related to the proximity to onset of menstruation and to levels of progesterone. The evidence suggests that caffeine elimination may be slowed in the late luteal phase, prior to the onset of menstruation. Such a reduction would lead to increased accumulation of caffeine with repeated self-administration during the day, but the effect may be too small to be of clinical significance in the majority of women.

Full Text

Duke Authors

Cited Authors

  • Lane, JD; Steege, JF; Rupp, SL; Kuhn, CM

Published Date

  • 1992

Published In

Volume / Issue

  • 43 / 5

Start / End Page

  • 543 - 546

PubMed ID

  • 1483492

International Standard Serial Number (ISSN)

  • 0031-6970

Digital Object Identifier (DOI)

  • 10.1007/BF02285099


  • eng

Conference Location

  • Germany