Tolerance to the reinforcing effects of cocaine.
Publication
, Journal Article
Emmett-Oglesby, MW; Lane, JD
Published in: Behav Pharmacol
June 1992
This study tested the hypothesis that prolonged exposure to high doses of cocaine would produce tolerance to the reinforcing effects of cocaine. We determined the rate of administration of low doses of cocaine in rats and then exposed these subjects to high doses of cocaine (5mg) three-times a day for 1 week. This treatment caused a 2-fold faster intake of cocaine, and the lowest dose of cocaine that would maintain self-administration was double the previous threshold dose. To our knowledge this is the first controlled demonstration of tolerance to the reinforcing effects of cocaine produced by chronic exposure to the drug, and we suggest that this tolerance may be a key marker for the development of drug dependence.
Duke Scholars
Published In
Behav Pharmacol
EISSN
1473-5849
Publication Date
June 1992
Volume
3
Issue
3
Start / End Page
193 / 200
Location
England
Related Subject Headings
- Neurology & Neurosurgery
- 1115 Pharmacology and Pharmaceutical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Emmett-Oglesby, M. W., & Lane, J. D. (1992). Tolerance to the reinforcing effects of cocaine. Behav Pharmacol, 3(3), 193–200.
Emmett-Oglesby, M. W., and J. D. Lane. “Tolerance to the reinforcing effects of cocaine.” Behav Pharmacol 3, no. 3 (June 1992): 193–200.
Emmett-Oglesby MW, Lane JD. Tolerance to the reinforcing effects of cocaine. Behav Pharmacol. 1992 Jun;3(3):193–200.
Emmett-Oglesby, M. W., and J. D. Lane. “Tolerance to the reinforcing effects of cocaine.” Behav Pharmacol, vol. 3, no. 3, June 1992, pp. 193–200.
Emmett-Oglesby MW, Lane JD. Tolerance to the reinforcing effects of cocaine. Behav Pharmacol. 1992 Jun;3(3):193–200.
Published In
Behav Pharmacol
EISSN
1473-5849
Publication Date
June 1992
Volume
3
Issue
3
Start / End Page
193 / 200
Location
England
Related Subject Headings
- Neurology & Neurosurgery
- 1115 Pharmacology and Pharmaceutical Sciences