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Evaluation of synthetic phospholipid ultrasound contrast agents.

Publication ,  Journal Article
Hasik, MJ; Kim, DH; Howle, LE; Needham, D; Prush, DP
Published in: Ultrasonics
November 2002

The echogenic properties of synthetic, phospholipid encapsulated, air-filled microbubbles with various carbon-chain length as ultrasound contrast agents are investigated through the use of a flow-through laboratory ultrasound system. Specifically, we investigate the effect of shell carbon-chain length on the ultrasonic signal for a variety of flow rates. Averaged, integrated backscatter power measurements from the lipid encapsulated agents are benchmarked against those of Albunex (Albunex is a registered trademark of Molecular Biosystems, Inc., San Diego, CA), a commercially available, air-filled protein microbubbles contrast agent, approved for clinical use in echocardiography in the United States by the Food and Drug Administration. We find that the lipid encapsulated agents sustain less damage leading to gas dissolution or particle destruction as compared to Albunex in the slow-flow studies performed. The carbon-chain length of the encapsulating lipid molecule is shown not to observably affect the backscattered amplitude of ultrasound at flow velocities exceeding 7 mm/s.

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Published In

Ultrasonics

DOI

EISSN

1874-9968

ISSN

0041-624X

Publication Date

November 2002

Volume

40

Issue

9

Start / End Page

973 / 982

Related Subject Headings

  • Ultrasonics
  • Phosphatidylcholines
  • Particle Size
  • Contrast Media
  • Acoustics
  • 5103 Classical physics
  • 4017 Mechanical engineering
  • 4016 Materials engineering
  • 0913 Mechanical Engineering
  • 0912 Materials Engineering
 

Citation

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Hasik, M. J., Kim, D. H., Howle, L. E., Needham, D., & Prush, D. P. (2002). Evaluation of synthetic phospholipid ultrasound contrast agents. Ultrasonics, 40(9), 973–982. https://doi.org/10.1016/s0041-624x(02)00384-0
Hasik, Matthew J., Dennis H. Kim, Laurens E. Howle, David Needham, and Donald P. Prush. “Evaluation of synthetic phospholipid ultrasound contrast agents.Ultrasonics 40, no. 9 (November 2002): 973–82. https://doi.org/10.1016/s0041-624x(02)00384-0.
Hasik MJ, Kim DH, Howle LE, Needham D, Prush DP. Evaluation of synthetic phospholipid ultrasound contrast agents. Ultrasonics. 2002 Nov;40(9):973–82.
Hasik, Matthew J., et al. “Evaluation of synthetic phospholipid ultrasound contrast agents.Ultrasonics, vol. 40, no. 9, Nov. 2002, pp. 973–82. Epmc, doi:10.1016/s0041-624x(02)00384-0.
Hasik MJ, Kim DH, Howle LE, Needham D, Prush DP. Evaluation of synthetic phospholipid ultrasound contrast agents. Ultrasonics. 2002 Nov;40(9):973–982.
Journal cover image

Published In

Ultrasonics

DOI

EISSN

1874-9968

ISSN

0041-624X

Publication Date

November 2002

Volume

40

Issue

9

Start / End Page

973 / 982

Related Subject Headings

  • Ultrasonics
  • Phosphatidylcholines
  • Particle Size
  • Contrast Media
  • Acoustics
  • 5103 Classical physics
  • 4017 Mechanical engineering
  • 4016 Materials engineering
  • 0913 Mechanical Engineering
  • 0912 Materials Engineering